An integrated full-head OPM-MEG system based on 128 zero-field sensors

被引：34

作者：

Alem, Orang ^{[1
,2
,3
]}

Hughes, K. Jeramy ^{[1
,2
,3
]}

Buard, Isabelle ^{[4
]}

Cheung, Teresa P. ^{[1
,5
,6
]}

Maydew, Tyler ^{[1
]}

Griesshammer, Andreas ^{[1
]}

Holloway, Kendall ^{[1
]}

Park, Aaron ^{[1
]}

Lechuga, Vanessa ^{[1
]}

Coolidge, Collin ^{[1
]}

Gerginov, Marja ^{[2
]}

Quigg, Erik ^{[2
]}

Seames, Alexander ^{[4
]}

Kronberg, Eugene ^{[4
]}

Teale, Peter ^{[4
]}

Knappe, Svenja ^{[1
,2
,3
]}

机构：

[1] FieldLine Med, Boulder, CO 80301 USA

[2] Univ Colorado Boulder, Paul M Rady Dept Mech Engn, Boulder, CO 80309 USA

[3] FieldLine Ind, Boulder, CO 80301 USA

[4] Univ Colorado Denver, Anschutz Med Campus, Denver, CO USA

[5] Simon Fraser Univ, Sch Engn, Burnaby, BC, Canada

[6] Fraser Hlth Author, Surrey Mem Hosp, Surrey, BC, Canada

来源：

FRONTIERS IN NEUROSCIENCE | 2023年 / 17卷

基金：

美国国家卫生研究院;

关键词：

optically-pumped magnetometer; HEDscan; magnetoencephalography; system integration; cross-validation; OPM; ATOMIC MAGNETOMETER; PERFORMANCE;

D O I：

10.3389/fnins.2023.1190310

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Compact optically-pumped magnetometers (OPMs) are now commercially available with noise floors reaching 10 fT/Hz(1/2). However, to be used effectively for magnetoencephalography (MEG), dense arrays of these sensors are required to operate as an integrated turn-key system. In this study, we present the HEDscan, a 128-sensor OPM MEG system by FieldLine Medical, and evaluate its sensor performance with regard to bandwidth, linearity, and crosstalk. We report results from cross-validation studies with conventional cryogenic MEG, the Magnes 3,600 WH Biomagnetometer by 4-D Neuroimaging. Our results show high signal amplitudes captured by the OPM-MEG system during a standard auditory paradigm, where short tones at 1000 Hz were presented to the left ear of six healthy adult volunteers. We validate these findings through an event-related beamformer analysis, which is in line with existing literature results.

引用

页数：8

共 31 条

[1] Nonlinear spectroscopy with a vertical-cavity surface-emitting laser (VCSEL) [J].

Affolderbach, C ;

Nagel, A ;

Knappe, S ;

Jung, C ;

Wiedenmann, D ;

Wynands, R .

APPLIED PHYSICS B-LASERS AND OPTICS, 2000, 70 (03) :407-413

[2] Magnetic field imaging with microfabricated optically-pumped magnetometers [J].

Alem, Orang ;

Mhaskar, Rahul ;

Jimenez-Martinez, Ricardo ;

Sheng, Dong ;

LeBlanc, John ;

Trahms, Lutz ;

Sander, Tilmann ;

Kitching, John ;

Knappe, Svenja .

OPTICS EXPRESS, 2017, 25 (07) :7849-7858

[3] High-sensitivity atomic magnetometer unaffected by spin-exchange relaxation [J].

Allred, JC ;

Lyman, RN ;

Kornack, TW ;

Romalis, MV .

PHYSICAL REVIEW LETTERS, 2002, 89 (13) :130801-130801

[4] Cross-Axis projection error in optically pumped magnetometers and its implication for magnetoencephalography systems [J].

Borna, Amir ;

Iivanainen, Joonas ;

Carter, Tony R. ;

McKay, Jim ;

Taulu, Samu ;

Stephen, Julia ;

Schwindt, Peter D. D. .

NEUROIMAGE, 2022, 247

[5] A 20-channel magnetoencephalography system based on optically pumped magnetometers [J].

Borna, Amir ;

Carter, Tony R. ;

Goldberg, Josh D. ;

Colombo, Anthony P. ;

Jau, Yuan-Yu ;

Berry, Christopher ;

Mckay, Jim ;

Stephen, Julia ;

Weisend, Michael ;

Schwindt, Peter D. D. .

PHYSICS IN MEDICINE AND BIOLOGY, 2017, 62 (23) :8909-8923

[6] A new generation of magnetoencephalography: Room temperature measurements using optically-pumped magnetometers [J].

Boto, Elena ;

Meyer, Sofie S. ;

Shah, Vishal ;

Alem, Orang ;

Knappe, Svenja ;

Kruger, Peter ;

Fromhold, T. Mark ;

Lim, Mark ;

Glover, Paul M. ;

Morris, Peter G. ;

Bowtell, Richard ;

Barnes, Gareth R. ;

Brookes, Matthew J. .

NEUROIMAGE, 2017, 149 :404-414

[7] On the Potential of a New Generation of Magnetometers for MEG: A Beamformer Simulation Study [J].

Boto, Elena ;

Bowtell, Richard ;

Kruger, Peter ;

Fromhold, T. Mark ;

Morris, Peter G. ;

Meyer, Sofie S. ;

Barnes, Gareth R. ;

Brookes, Matthew J. .

PLOS ONE, 2016, 11 (08)

[8] VARIOUS LEVEL CROSSING RESONANCES ON ATOMS PUMPED OPTICALLY IN ZERO FIELD .1. THEORY [J].

COHENTANNOUDJI, C ;

DUPONTRO.J ;

HAROCHE, S ;

LALOE, F .

REVUE DE PHYSIQUE APPLIQUEE, 1970, 5 (01) :95-+

[9] DETECTION OF VERY WEAK MAGNETIC FIELDS (10-9GAUSS) BY 87RB-ZERO-FIELD LEVEL CROSSING RESONANCES [J].

DUPONTRO.J ;

HAROCHE, S ;

COHENTAN.C .

PHYSICS LETTERS A, 1969, A 28 (09) :638-&

[10] MEG and EEG data analysis with MNE-Python']Python [J].

Gramfort, Alexandre ;

Luessi, Martin ;

Larson, Eric ;

Engemann, Denis A. ;

Strohmeier, Daniel ;

Brodbeck, Christian ;

Goj, Roman ;

Jas, Mainak ;

Brooks, Teon ;

Parkkonen, Lauri ;

Haemaelaeinen, Matti .

FRONTIERS IN NEUROSCIENCE, 2013, 7

← 1 2 3 4 →