Effect of body tissue composition on the outcome of patients with metastatic non-small cell lung cancer treated with PD-1/PD-L1 inhibitors

被引:6
作者
Makrakis, Dimitrios [1 ,2 ]
Rounis, Konstantinos [1 ,3 ]
Tsigkas, Alexandros-Pantelis [4 ]
Georgiou, Alexandra [4 ]
Galanakis, Nikolaos [5 ]
Tsakonas, George [3 ,6 ]
Ekman, Simon [3 ,6 ]
Papadaki, Chara [7 ]
Monastirioti, Alexia [7 ]
Kontogianni, Meropi [4 ]
Gioulbasanis, Ioannis [8 ]
Mavroudis, Dimitris [1 ,7 ]
Agelaki, Sofia [1 ,7 ]
机构
[1] Univ Gen Hosp, Dept Med Oncol, Iraklion, Crete, Greece
[2] Albert Einstein Coll Med, Jacobi Med Ctr, The Bronx, NY 10461 USA
[3] Karolinska Univ Hosp, Comprehens Canc Ctr, Stockholm, Sweden
[4] Harokopio Univ, Sch Hlth Sci & Educ, Dept Nutr & Dietet, Athens, Greece
[5] Univ Gen Hosp, Dept Med Imaging, Iraklion, Crete, Greece
[6] Karolinska Inst, Dept Oncol Pathol, Stockholm, Sweden
[7] Univ Crete, Sch Med, Lab Translat Oncol, Iraklion, Greece
[8] Animus Kyanus Stavros Gen Clin, Dept Med Oncol, Larisa, Greece
来源
PLOS ONE | 2023年 / 18卷 / 02期
关键词
ADIPOSE-TISSUE; SOLID TUMORS; VISCERAL FAT; OBESITY; CHEMOTHERAPY; SARCOPENIA; CACHEXIA; IMPACT; INFLAMMATION; PROGNOSIS;
D O I
10.1371/journal.pone.0277708
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Obesity and sarcopenia have been reported to affect outcomes in patients with non-small cell lung cancer (NSCLC) treated with immune checkpoint inhibitors (ICIs). We analyzed prospective data from 52 patients with non-oncogene driven metastatic NSCLC treated with ICIs. Body tissue composition was calculated by measuring the fat and muscle densities at the level of 3(rd) lumbar vertebra in each patient computed tomography scan before ICI initiation using sliceOmatic tomovision. We converted the densities to indices [Intramuscular Fat Index (IMFI), Visceral Fat Index (VFI), Subcutaneous Fat Index (SFI), Lumbar Skeletal Muscle Index (LSMI)] by dividing them by height in meters squared. Patients were dichotomized based on their baseline IMFI, VFI and SFI according to their gender-specific median value. The cut-offs that were set for LMSI values were 55 cm(2)/m(2) for males and 39 cm(2)/m(2) for females. SFI distribution was significantly higher (p = 0.040) in responders compared to non-responders. None of the other variables affected response rates. Low LSMI HR: 2.90 (95% CI: 1.261-6.667, p = 0.012) and low SFI: 2.20 (95% CI: 1.114-4.333, p = 0.023) values predicted for inferior OS. VFI and IMFI values did not affect survival. Subcutaneous adipose and skeletal muscle tissue composition significantly affected immunotherapy outcomes in our cohort.
引用
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页数:16
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