Posterior reversible encephalopathy syndrome and autoimmunity

被引:6
作者
Li, Yang [1 ]
Song, Junmin [2 ,5 ]
Huq, Ahm M. [3 ]
Timilsina, Suraj [4 ]
Gershwin, M. Eric [4 ]
机构
[1] China Med Univ, Dept Crit Care Med, Shengjing Hosp, Shenyang 110004, Liaoning, Peoples R China
[2] China Med Univ, Dept Gastroenterol, Shengjing Hosp, Shenyang 110004, Liaoning, Peoples R China
[3] Cent Michigan Univ, Dept Pediat, Detroit, MI 48201 USA
[4] Univ Calif Davis, Sch Med, Div Rheumatol Allergy & Clin Immunol, Davis, CA 95616 USA
[5] China Med Univ, Dept Gastroenterol, Shengjing Hosp, 36 Sanhao St, Shenyang 110004, Liaoning, Peoples R China
关键词
Posterior reversible encephalopathy syndrome; Leukoencephalopathy; Vasogenic edema; Autoimmunity; Lupus; Vascular endothelial growth factor; SYSTEMIC-LUPUS-ERYTHEMATOSUS; BRAIN-BARRIER DYSFUNCTION; ENDOTHELIAL GROWTH-FACTOR; SICKLE-CELL-DISEASE; CEREBROSPINAL-FLUID; SYNDROME PRES; CEREBRAL EDEMA; PATHOGENESIS; AUTOANTIBODIES; SPECTRUM;
D O I
10.1016/j.autrev.2022.103239
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Posterior reversible encephalopathy syndrome (PRES) is a clinical syndrome characterized by acute or subacute onset of neurological symptoms (e.g., headache, seizure, confusion, vomiting, and diminished eyesight) and impaired endothelial barrier function of the cerebral circulation that leads to bilateral subcortical vasogenic edema, while exhibiting a "reversible" feature in most cases. Clinically, various predisposing or precipitating conditions have been identified, such as hypertension, autoimmune diseases, renal dysfunction/failure, pre-eclampsia/eclampsia, post-transplantation conditions, and certain therapeutic agents. Among several putative mechanisms, the immune activation hypothesis prevails, as up to 50% of patients with PRES harbor abnor-malities related to autoimmunity, such as concurrent systemic lupus erythematosus. In this Review, we sum-marize the clinical and laboratory evidence that places PRES in the context of autoimmunity.
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页数:9
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