Real-Time Objective Evaluation of the Ischemic Stroke through pH-Responsive Fluorescence Imaging

被引：9

作者：

Yao, Shasha ^{[1
,2
]}

He, Chengbin ^{[3
]}

Yuan, Pengcheng ^{[1
,2
]}

Xu, Xiaodan ^{[2
]}

Zhou, Xiaoxuan ^{[3
]}

Shen, Liyin ^{[4
]}

Hu, Qiuhui ^{[3
]}

Slater, Nigel K. H. ^{[1
,2
]}

Sun, Wenjing ^{[2
]}

Shen, Youqing ^{[1
]}

Hu, Hongjie ^{[3
]}

Tang, Jianbin ^{[1
,2
,3
]}

机构：

[1] Zhejiang Univ, Coll Chem & Biol Engn, Key Lab Smart Biomat Zhejiang Prov, Hangzhou 310027, Zhejiang, Peoples R China

[2] ZJU Hangzhou Global Sci & Technol Innovat Ctr, Hangzhou 311215, Zhejiang, Peoples R China

[3] Zhejiang Univ, Sir Run Run Shaw Hosp SRRSH, Sch Med, Dept Radiol, Hangzhou 310016, Zhejiang, Peoples R China

[4] Zhejiang Univ, Dept Polymer Sci & Engn, MOE Key Lab Macromol Synth & Functionalizat, Hangzhou 310027, Peoples R China

来源：

ADVANCED HEALTHCARE MATERIALS | 2023年 / 12卷 / 09期

基金：

中国国家自然科学基金; 国家重点研发计划;

关键词：

ischemic stroke; neurological deficit score; NIR fluorescence imaging; pH-responsibility; CEREBRAL-ARTERY OCCLUSION; HEALTH-CARE PROFESSIONALS; EARLY MANAGEMENT; 2018; GUIDELINES; BRAIN; TISSUE; MODEL;

D O I：

10.1002/adhm.202201981

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

A rapid and comprehensive assessment of ischemic stroke (IS) is critical for clinicians to take the most appropriate treatment. Currently, IS assessment is mainly carried out by computed tomography and magnetic resonance imaging in combination with observing the clinical symptoms and inquiring about contraindications. However, they cannot diagnose pathological conditions and judge the microenvironment in real-time. Near-infrared fluorescence imaging has advantages for IS imaging, such as high sensitivity, high spatiotemporal resolution, and straightforward real-time operation. Herein, a pH-responsive fluorescent liposomal probe (BOD@Lip) is prepared for in vivo real-time visualization of the degree of IS based on the different acid microenvironments in the progression of the disease. The fluorescence imaging with BOD@Lip shows the degree of IS, and the correlation between fluorescence signals and the neurological deficit scores is established for the first time. This work provides a new method to objectively evaluate the degree of IS through a visualized route and a new insight into the relationship between the acidic microenvironment and the progression of IS.

引用

页数：8

共 32 条

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