Lifestyle intervention in ovarian cancer enhanced survival (LIVES) study (NRG/GOG0225): Recruitment, retention and baseline characteristics of a randomized trial of diet and physical activity in ovarian cancer survivors

被引：11

作者：

Thomson, Cynthia A. ^{[1
]}

Crane, Tracy E. ^{[1
,2
]}

Miller, Austin ^{[3
]}

Gold, Michael A. ^{[4
]}

Powell, Matthew ^{[5
]}

Bixel, Kristin ^{[6
,7
]}

Van Le, Linda ^{[8
]}

DiSilvestro, Paul ^{[9
]}

Ratner, Elena ^{[10
]}

Lele, Shashikant ^{[11
]}

Guntupalli, Saketh ^{[12
]}

Huh, Warner ^{[13
]}

Robertson, Sharon E. ^{[14
]}

Modesitt, Susan ^{[15
]}

Casey, A. Catherine ^{[16
]}

Basen-Engquist, Karen ^{[17
,18
]}

Skiba, Meghan ^{[1
]}

Walker, Joan ^{[19
]}

Kachnic, Lisa ^{[20
]}

Alberts, David S. ^{[21
]}

机构：

[1] Univ Arizona, Mel & Enid Zuckerman Coll Publ Hlth, 1250 N Martin Ave,Room A260, Tucson, AZ 85724 USA

[2] Univ Miami, Miller Sch Med, Sylvester Comprehens Canc Ctr, Div Med Oncol, Miami, FL 33136 USA

[3] Roswell Pk Comprehens Canc Ctr, Clin Trials Dev Div, NRG Oncol, Biostat & Bioinformat, Buffalo, NY USA

[4] Oklahoma Canc Specialists & Res Inst, Tulsa, OK USA

[5] Washington Univ, Sch Med, St Louis, MO USA

[6] Ohio State Univ, Comprehens Canc Ctr, James Canc Hosp, Columbus, OH 43210 USA

[7] Solove Res Inst, Columbus, OH USA

[8] Univ North Carolina, Sch Med, UNC Hosp, 101 Manning Dr, Chapel Hill, NC 27515 USA

[9] Women & Infants, 101 Dudley St, Providence, RI USA

[10] Yale Univ, Sch Med, New Haven, CT USA

[11] Roswell Pk Comprehens Canc Ctr, Buffalo, NY USA

[12] Univ Colorado, Ctr Canc, Anschutz Canc Pavil, Aurora, CO USA

[13] Univ Alabama Birmingham, Birmingham Hosp, Birmingham, AL USA

[14] Indiana Univ Hlth, Simon Canc Ctr, Indianapolis, IN USA

[15] Univ Virginia, Emily Cour Clin Canc Ctr, Charlottesville, VA USA

[16] Edina Clin, US Oncol, Edina, MN USA

[17] Univ Texas MD Anderson Canc Ctr, Behav Sci, Houston, TX 77030 USA

[18] Univ Texas MD Anderson Canc Ctr, Ctr Energy Balance Canc Prevent & Survivorship, Houston, TX 77030 USA

[19] Univ Oklahoma, Oklahoma City, OK USA

[20] Columbia Univ, Herbert Irving Comprehens Canc Ctr, New York, NY USA

[21] Univ Arizona, Ctr Canc, Med Pharmacol Publ Hlth Nutrit Sci & BIO5, Tucson, AZ 85719 USA

来源：

GYNECOLOGIC ONCOLOGY | 2023年 / 170卷

关键词：

Ovarian cancer; Cancer survivorship; Lifestyle; Diet; Physical activity; Progression-free survival; Nutrition; Exercise; Vegetables; Fruit; Fiber; Fat; Steps; FREQUENCY QUESTIONNAIRE; HEALTH; NUTRITION; MORTALITY; WOMEN; INDEX; RISK;

D O I：

10.1016/j.ygyno.2022.12.017

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Objective. The Lifestyle Intervention for oVarian cancer Enhanced Survival (LIVES) is a national study of a combined diet and physical activity intervention for stage II-IV ovarian cancer survival, an under-represented cancer in lifestyle behavioral intervention research. Here, we present the data on recruitment, retention, and baseline demographic, clinical and lifestyle behavior characteristics of the LIVES study participants.Methods. The LIVES study (NRG Oncology/GOG 0225) is a Phase III diet plus physical activity intervention trial testing the hypothesis that ovarian cancer survivors in the lifestyle intervention will demonstrate better progression-free survival than those in the control condition. Study interventions were delivered via centralized telephone-based health coaching. Baseline descriptive statistics were computed for demographic, clinical, and lifestyle behavior characteristics.Results. The LIVES study exceeded its recruitment goals, enrolling 1205 ovarian cancer survivors from 195 NRG/NCORP-affiliated oncology practices across 49 states from 2012 to 2018. The mean age of enrollees was 59.6 years; the majority (69.4%) with stage III disease; 89% White, 5.5% Hispanic; 64% overweight/obese. Baseline self-reported diet showed a mean daily intake of 6.6 servings of fruit and vegetables, 62.7 fat grams, and 21.7 g of fiber. Physical activity averaged 13.0 MET-hours/week of moderate to vigorous physical activity; 50.9 h/week of sedentary time. Retention rates exceeded 88%.Conclusion. The LIVES study demonstrates efficiency in recruiting and retaining ovarian cancer survivors in a 24-month study of diet and physical activity intervention with a primary endpoint of progression free survival that will be reported.Trial registration. ClinicalTrials.gov NCT00719303.(c) 2022 Published by Elsevier Inc.

引用

页码：11 / 18

页数：8

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