Early and late basilar artery thrombectomy time window outcomes

被引：3

作者：

Mierzwa, Adam T. ^{[1
,2
]}

Rao, Rahul ^{[1
,2
]}

Al Kasab, Sami ^{[3
]}

Nelson, Ashley ^{[3
]}

Ortega-Gutierrez, Santiago ^{[4
]}

Vivanco-Suarez, Juan ^{[4
]}

Farooqui, Mudassir ^{[4
]}

Jadhav, Ashutosh P. ^{[5
]}

Desai, Shashvat ^{[5
]}

Toth, Gabor ^{[6
]}

Alrohimi, Anas ^{[6
]}

Nguyen, Thanh N. ^{[7
]}

Klein, Piers ^{[7
]}

Abdalkader, Mohamad ^{[7
]}

Salahuddin, Hisham ^{[8
]}

Pandey, Aditya ^{[9
]}

Wilseck, Zachary ^{[9
]}

Koduri, Sravanthi ^{[9
]}

Vora, Nirav ^{[10
]}

Aladamat, Nameer ^{[1
]}

Gharaibeh, Khaled ^{[1
]}

Afreen, Ehad ^{[1
,2
]}

Zaidi, Syed ^{[1
,2
]}

Jumaa, Mouhammad ^{[1
,2
]}

机构：

[1] Univ Toledo, Dept Neurol, Coll Med & Life Sci, Toledo, OH 43614 USA

[2] Promed Stroke Network, Toledo, OH 43606 USA

[3] Med Univ South Carolina, Dept Neurol & Neurosurg, Charleston, SC USA

[4] Univ Iowa, Iowa City, IA USA

[5] Barrow Neurol Inst, Phoenix, AZ USA

[6] Cleveland Clin Fdn, Cleveland, OH USA

[7] Boston Univ, Dept Neurol Radiol, Chobanian & Avedisian Sch Med, Boston, MA USA

[8] Antelope Valley Hosp, Dept Neurol, Los Angeles, CA USA

[9] Univ Michigan, Dept Neurosurg, Ann Arbor, MI USA

[10] OhioHlth Riverside Methodist Hosp, Columbus, OH USA

来源：

FRONTIERS IN NEUROLOGY | 2024年 / 15卷

关键词：

stroke; basilar artery; thrombectomy; large-vessel occlusion; time window; ENDOVASCULAR TREATMENT; ISCHEMIC-STROKE; OCCLUSION; THERAPY; TRIAL; BRAIN;

D O I：

10.3389/fneur.2024.1352310

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Importance: Stroke-to-recanalization time is a strong predictor of outcomes in anterior circulation large-vessel occlusion (LVO). The authors aimed to evaluate functional outcomes in early (<6 h) vs. late (6-24 h) time windows for thrombectomy-treated basilar artery occlusions. Methods: Patients were derived from the Posterior Circulation Ischemic Stroke Evaluation: Analyzing Radiographic and Intra-procedural Predictors of Mechanical Thrombectomy (PC-SEARCH) Registry and retrospectively analyzed early and late basilar artery thrombectomy time windows cohorts. Patients were dichotomized based on the last known well and correlated to 90-day functional outcomes (mRS 0-3). A multiple logistic regression analysis was performed. Results: A total of 405 patients were included in this study: 216 and 189 patients in the early and late time windows, respectively. Baseline demographic, stroke, radiographic, and intraprocedural characteristics were similar between the groups. A total of 99 (46%) and 79 (42%) patients in the early and late time windows, respectively, achieved favorable functional outcomes at 90 days (p = 0.41), and multiple logistic regression analysis did not reveal differences between cohorts (OR: 0.74; 95% CI: 0.46-1.19; p = 0.22). Symptomatic hemorrhage (7% vs. 5%; p = 0.69) and neurological complications (8% vs. 9%; p = 0.83) were similar between the groups; however, hospital complications were more common in the early time window cohort (22% vs. 13%; p = 0.01). Conclusion: The early and late thrombectomy time windows can achieve similar rates of 90-day favorable functional outcomes. However, timely thrombectomy influences the likelihood of achieving excellent functional outcomes (mRS <= 2) within the early time window.

引用

页数：8

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