The Multifaceted S100B Protein: A Role in Obesity and Diabetes?

被引：8

作者：

Michetti, Fabrizio ^{[1
,2
,3
,4
]}

Di Sante, Gabriele ^{[5
]}

Clementi, Maria Elisabetta ^{[1
]}

Valeriani, Federica ^{[6
]}

Mandarano, Martina ^{[7
]}

Ria, Francesco ^{[8
]}

Di Liddo, Rosa ^{[9
]}

Rende, Mario ^{[5
]}

Spica, Vincenzo Romano ^{[6
]}

机构：

[1] Ist Sci & Tecnol Chim Giulio Natta SCITEC CNR, Lgo F Vito 1, I-00168 Rome, Italy

[2] Univ Cattolica Sacro Cuore, Dept Neurosci, Lgo F Vito 1, I-00168 Rome, Italy

[3] LUM Univ, Dept Med, I-70010 Casamassima, Italy

[4] Genes, Via Venti Settembre 118, I-00187 Rome, Italy

[5] Univ Perugia, Dept Med & Surg, Sect Human Clin & Forens Anat, I-06132 Perugia, Italy

[6] Univ Rome Foro Italico, Dept Movement Human & Hlth Sci, I-00135 Rome, Italy

[7] Univ Perugia, Med Sch, Dept Med & Surg, Sect Anat Pathol & Histol, I-06132 Perugia, Italy

[8] Univ Cattolica Sacro Cuore, Dept Translat Med & Surg, Sect Gen Pathol, I-00168 Rome, Italy

[9] Univ Padua, Dept Pharmaceut & Pharmacol Sci, I-35131 Padua, Italy

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2024年 / 25卷 / 02期

关键词：

S100B protein; adipose tissue; obesity; diabetes; S-100; PROTEIN; ADIPOSE-TISSUE; SERUM-LEVELS; ADIPOCYTES; MELLITUS; CELLS;

D O I：

10.3390/ijms25020776

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The S100B protein is abundant in the nervous system, mainly in astrocytes, and is also present in other districts. Among these, the adipose tissue is a site of concentration for the protein. In the light of consistent research showing some associations between S100B and adipose tissue in the context of obesity, metabolic disorders, and diabetes, this review tunes the possible role of S100B in the pathogenic processes of these disorders, which are known to involve the adipose tissue. The reported data suggest a role for adipose S100B in obesity/diabetes processes, thus putatively re-proposing the role played by astrocytic S100B in neuroinflammatory/neurodegenerative processes.

引用

页数：12

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