Unveiling the link between genetic alterations in gamma secretase and BCMA surface density in multiple myeloma

被引：0

作者：

Cowan, Andrew J. ^{[1
]}

Green, Damian J. ^{[1
]}

机构：

[1] UW Med, Fred Hutch Canc Ctr, Seattle, WA 98195 USA

来源：

BRITISH JOURNAL OF HAEMATOLOGY | 2024年 / 204卷 / 02期

关键词：

gamma secretase; genetic alterations; multiple myeloma; T-CELL THERAPY;

D O I：

10.1111/bjh.19222

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Cattaneo et al. report a unique case of a multiple myeloma patient with elevated B-cell maturation antigen (BCMA) surface density, potentially due to genetic alterations in the gamma-secretase protease complex-responsible for BCMA cleavage from plasma cells. No mutations in the BCMA gene were detected, but there was partial deletion of PSEN1 and amplification of PSEN2 (components of the gamma-secretase complex), which may explain the lack of response to the gamma-secretase inhibitor DAPT. This case, along with recent published literature, underscores the significance of gamma secretase in modulating BCMA density and the potential impact of its genetic alterations.

引用

页码：391 / 392

页数：2

共 9 条

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