A case of false positive opiate immunoassay results from rifampin (rifampicin) treatment

被引：1
|
作者：
Lam, K. H. Brian [1 ]
Song, Lu [1 ]
Buggs, Vincent [1 ]
Vithlani, Gopal [1 ]
Metushi, Imir G. [1 ,2 ]
机构：
[1] Univ Calif Los Angeles, David Geffen Sch Med, Dept Pathol & Lab Med, Los Angeles, CA USA
[2] Dept Pathol & Lab Med, 10833 Le Conte Ave CHS A3-231S, Los Angeles, CA 90095 USA
来源：
PRACTICAL LABORATORY MEDICINE | 2023年 / 37卷
关键词：
Rifampin; Opiate; HPLC; LC-MS/MS; False-positive;
D O I：
10.1016/j.plabm.2023.e00334
中图分类号：
R446 [实验室诊断]; R-33 [实验医学、医学实验];
学科分类号：
1001 ;
摘要：
The drug screen test on a 12-year-old male patient was positive for opiates by a kinetic interaction of microparticles in solution (KIMS) immunoassay method on the Roche Cobas C502. The positive opiates result was not confirmed by the liquid chromatography-tandem mass spectrometry (LCMS/MS) method. A chart review revealed that the patient had tuberculosis and was on rifampin. We spiked rifampin into drug-free urine and tested opiates with the Cobas method. Once again, a positive result was obtained. This case showed that rifampin can still cause false positive opiate results measured with the KIMS method. We want to stress the importance of confirming positive screen results by more specific methods such as LC-MS/MS.
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页数：3
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