Interpreting cardiac biomarkers in small animal practice

被引：0

作者：

Bode, Liz ^{[1
]}

Lau, Stephanie ^{[2
]}

机构：

[1] Univ Liverpool, Liverpool, England

[2] Royal Vet Coll, London, England

来源：

IN PRACTICE | 2023年 / 45卷 / 07期

关键词：

BRAIN NATRIURETIC PEPTIDE; TROPONIN-I CONCENTRATION; MITRAL-VALVE DISEASE; HEART-FAILURE; NT-PROBNP; BIOLOGIC VARIABILITY; DOGS; CATS; ONSET; DEATH;

D O I：

10.1002/inpr.349

中图分类号：

S85 [动物医学（兽医学）];

学科分类号：

0906 ;

摘要：

Background: Cardiac troponin-I (cTnI) and N-terminal pro B-type natriuretic peptide (NT-proBNP) are two cardiac biomarkers readily available on the market. These two biomarkers are useful diagnostic tools used in the right setting: differentiating cardiac and non-cardiac causes of respiratory distress and providing prognosis prediction. However, these tests have their limitations and their results should be interpreted with these limitations in mind.Aim of the article: This article reviews the available evidence around the physiology of cTnI and NT-proBNP - the commercially available assays - and discusses their indications, limitations and result interpretation for each biomarker. The emerging biomarker, microRNA, is also briefly discussed.

引用

收藏

页码：372 / 382

页数：7

相关论文

共 24 条

[1] The predictive value of clinical, radiographic, echocardiographic variables and cardiac biomarkers for assessing risk of the onset of heart failure or cardiac death in dogs with preclinical myxomatous mitral valve disease enrolled in the DELAY study [J].

Borgarelli, M. ;

Ferasin, L. ;

Lamb, K. ;

Chiavegato, D. ;

Bussadori, C. ;

D'Agnolo, G. ;

Migliorini, F. ;

Poggi, M. ;

Santilli, R. A. ;

Guillot, E. ;

Garelli-Paar, C. ;

Corneliani, R. Toschi ;

Farina, F. ;

Zani, A. ;

Dirven, M. ;

Smets, P. ;

Guglielmini, C. ;

Oliveira, P. ;

Di Marcello, M. ;

Porciello, F. ;

Crosara, S. ;

Ciaramella, P. ;

Piantedosi, D. ;

Smith, S. ;

Vannini, S. ;

Dall'Aglio, E. ;

Savarino, P. ;

Quintavalla, C. ;

Patteson, M. ;

Silva, J. ;

Locatelli, C. ;

Toaldo, M. Baron .

JOURNAL OF VETERINARY CARDIOLOGY, 2021, 36 :77-88

[2] Plasma Cardiac Troponin I Concentration and Cardiac Death in Cats with Hypertrophic Cardiomyopathy [J].

Borgeat, K. ;

Sherwood, K. ;

Payne, J. R. ;

Fuentes, V. Luis ;

Connolly, D. J. .

JOURNAL OF VETERINARY INTERNAL MEDICINE, 2014, 28 (06) :1731-1737

[3] Analytical validation of a second-generation immunoassay for the quantification of N-terminal pro-B-type natriuretic peptide in canine blood [J].

Cahill, Roberta J. ;

Pigeon, Kathleen ;

Strong-Townsend, Marilyn I. ;

Drexel, Jan P. ;

Clark, Genevieve H. ;

Buch, Jesse S. .

JOURNAL OF VETERINARY DIAGNOSTIC INVESTIGATION, 2015, 27 (01) :61-67

[4] Management of incidentally detected heart murmurs in dogs and cats [J].

Cote, Etienne ;

Edwards, N. Joel ;

Ettinger, Stephen J. ;

Fuentes, Virginia Luis ;

MacDonald, Kristin A. ;

Scansen, Brian A. ;

Sisson, D. David ;

Abbott, Jonathan A. .

JOURNAL OF VETERINARY CARDIOLOGY, 2015, 17 (04) :245-261

[5] Relationship of Plasma N- terminal Pro- brain Natriuretic Peptide Concentrations to Heart Failure Classification and Cause of Respiratory Distress in Dogs Using a 2nd Generation ELISA Assay [J].

Fox, P. R. ;

Oyama, M. A. ;

Hezzell, M. J. ;

Rush, J. E. ;

Nguyenba, T. P. ;

DeFrancesco, T. C. ;

Lehmkuhl, L. B. ;

Kellihan, H. B. ;

Bulmer, B. ;

Gordon, S. G. ;

Cunningham, S. M. ;

MacGregor, J. ;

Stepien, R. L. ;

Lefbom, B. ;

Adin, D. ;

Lamb, K. .

JOURNAL OF VETERINARY INTERNAL MEDICINE, 2015, 29 (01) :171-179

[6] Long-term biological variability and the generation of a new reference interval for plasma N-terminal pro-B-type natriuretic peptide in Labrador retrievers [J].

Gomart, S. ;

Allaway, D. ;

Harrison, M. ;

Dickson, D. ;

Seo, J. ;

Ferasin, L. ;

Payne, J. R. ;

Hezzell, M. J. ;

Borgeat, K. .

JOURNAL OF SMALL ANIMAL PRACTICE, 2020, 61 (06) :368-373

[7] Prospective evaluation of the combined value of physical examination and biomarker variables in screening for preclinical dilated cardiomyopathy in Doberman Pinschers [J].

Gordon, S. G. ;

Wesselowski, S. ;

Estrada, A. H. ;

Braz-Ruivo, L. ;

Morris, N. ;

Haggstrom, J. ;

O'Grady, M. R. ;

Malcolm, E. .

JOURNAL OF VETERINARY CARDIOLOGY, 2022, 40 :69-83

[8] Biologic variability of N-terminal pro-brain natriuretic peptide in adult healthy cats [J].

Harris, Autumn N. ;

Estrada, Amara H. ;

Gallagher, Alexander E. ;

Winter, Brandy ;

Lamb, Kenneth E. ;

Bohannon, Mary ;

Hanscom, Jancy ;

Mainville, Celine A. .

JOURNAL OF FELINE MEDICINE AND SURGERY, 2017, 19 (02) :216-223

[9] Differentiation of Cardiac from Noncardiac Pleural Effusions in Cats using Second-Generation Quantitative and Point-of-Care NT-proBNP Measurements [J].

Hezzell, M. J. ;

Rush, J. E. ;

Humm, K. ;

Rozanski, E. A. ;

Sargent, J. ;

Connolly, D. J. ;

Boswood, A. ;

Oyama, M. A. .

JOURNAL OF VETERINARY INTERNAL MEDICINE, 2016, 30 (02) :536-542

[10] The Combined Prognostic Potential of Serum High-Sensitivity Cardiac Troponin I and N-Terminal pro-B-Type Natriuretic Peptide Concentrations in Dogs with Degenerative Mitral Valve Disease [J].

Hezzell, M. J. ;

Boswood, A. ;

Chang, Y-M ;

Moonarmart, W. ;

Souttar, K. ;

Elliott, J. .

JOURNAL OF VETERINARY INTERNAL MEDICINE, 2012, 26 (02) :302-311