Surgical Treatment of Corneal Shield Ulcer in Vernal Keratoconjunctivitis: A Systematic Review

被引:1
|
作者
Azizi, Samim [1 ]
Subhi, Yousif [1 ,2 ]
Rasmussen, Marie Louise Roed [1 ,3 ]
机构
[1] Rigshosp, Dept Ophthalmol, DK-2100 Copenhagen, Denmark
[2] Univ Southern Denmark, Dept Clin Res, DK-5230 Odense, Denmark
[3] Univ Copenhagen, Dept Clin Med, DK-2100 Copenhagen, Denmark
来源
JOURNAL OF PERSONALIZED MEDICINE | 2023年 / 13卷 / 07期
关键词
shield ulcer; surgery; vernal keratoconjunctivitis; cornea; systematic review; TRIAMCINOLONE INJECTION; SUPRATARSAL INJECTION; MANAGEMENT; COMPLICATIONS; CYCLOSPORINE; DEBRIDEMENT; EFFICACY;
D O I
10.3390/jpm13071092
中图分类号
R19 [保健组织与事业(卫生事业管理)];
学科分类号
摘要
Background: Vernal keratoconjunctivitis (VKC) severely affects the quality of life of affected patients. The development of a shield ulcer is considered one of the most severe late-stage complications, which when untreated leads to irreversible vision loss. In this systematic review, we outlined the results of surgical treatments of corneal shield ulcers in VKC. Methods: We searched 12 literature databases on 3 April 2023 for studies of patients with VKC in which shield ulcers were treated by any surgical treatment. Treatment results were reviewed qualitatively. Assessments of the risk of bias of individual studies were made using the Clinical Appraisal Skills Programme. Results: Ten studies with 398 patients with VKC were eligible for the qualitative review. Two categories of surgical approaches were described: supratarsal corticosteroid injection and debridement with or without amniotic membrane transplantation. Almost all patients experienced resolution or improvement of their shield ulcers, regardless of treatment modality. Time to healing was faster with surgical debridement. A small proportion experienced recurrence and side effects. Conclusions: Surgical treatment for shield ulcers in VKC seems highly effective, but careful post-operative treatment and follow-ups are necessary due to the risk of recurrence and potential side effects.
引用
收藏
页数:12
相关论文
共 50 条
  • [21] Vernal keratoconjunctivitis: a major review
    Kumar, Sunil
    ACTA OPHTHALMOLOGICA, 2009, 87 (02) : 133 - 147
  • [22] Corneal biochemical features of patients with vernal keratoconjunctivitis
    Emre, Sinan
    Baser, Esin
    Ozturk, Bilge
    Zorlu, Sibel
    Uzun, Ozgur
    Gulhan, Ceren
    GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY, 2013, 251 (02) : 555 - 558
  • [23] Corneal and lens densitometry in patients with vernal keratoconjunctivitis
    Yilmaz, Yusuf Cem
    Ipek, Sefik Can
    Ozer, Muhammet Derda
    INTERNATIONAL OPHTHALMOLOGY, 2021, 41 (08) : 2667 - 2676
  • [24] Surgical Resection and Amniotic Membrane Transplantation for Treatment of Refractory Giant Papillae in Vernal Keratoconjunctivitis
    Guo, Ping
    Kheirkhah, Ahmad
    Zhou, Wei-wei
    Qin, Lei
    Shen, Xiao-li
    CORNEA, 2013, 32 (06) : 816 - 820
  • [25] Current and emerging treatment options for vernal keratoconjunctivitis
    Sacchetti, Marta
    Bruscolini, Alice
    Abicca, Irene
    Nebbioso, Marcella
    La Cava, Maurizio
    Bonini, Stefano
    Lambiase, Alessandro
    EXPERT OPINION ON ORPHAN DRUGS, 2017, 5 (04): : 343 - 353
  • [26] Superficial keratectomy and amniotic membrane patch in the treatment of corneal plaque of vernal keratoconjunctivitis
    Pelegrin, L.
    Gris, O.
    Adan, A.
    Plazas, A.
    EUROPEAN JOURNAL OF OPHTHALMOLOGY, 2008, 18 (01) : 131 - 133
  • [27] Corneal and lens densitometry withPentacamHRin children with vernal keratoconjunctivitis
    Caglayan, Mehtap
    Oncul, Hasan
    Alakus, Mehmet Fuat
    Dag, Umut
    CLINICAL AND EXPERIMENTAL OPTOMETRY, 2021, 104 (02) : 156 - 161
  • [28] Corneal topometric indices and proclivity toward corneal ectasia in vernal keratoconjunctivitis
    Yilmaz, Y. C.
    Ipek, S. C.
    Gobeka, H. H.
    JOURNAL FRANCAIS D OPHTALMOLOGIE, 2024, 47 (01):
  • [29] Assessment of Corneal Alterations by Confocal Microscopy in Vernal Keratoconjunctivitis
    Nebbioso, Marcella
    Zicari, Anna Maria
    Lollobrigida, Valeria
    Marenco, Marco
    Duse, Marzia
    SEMINARS IN OPHTHALMOLOGY, 2015, 30 (01) : 40 - 43
  • [30] Cyclosporine A and autologous serum efficacy for treatment of vernal keratoconjunctivitis
    Esmail, Ahmed
    Hashem, Ahmed O.
    Elashri, Mohammed
    Ibrahim, Mohamed Ahmed Hafez
    JOURNAL OF THE EGYPTIAN OPHTHALMOLOGICAL SOCIETY, 2024, 117 (02) : 108 - 118