0 Determination of Lincomycin in Milk Using Cu-Based Metal-Organic Framework Adsorbent and Liquid Chromatography-Tandem Mass Spectrometry

被引:7
作者
Li, Hanle [1 ]
Wu, Jinhai [1 ]
Bai, Jialei [2 ]
Wu, Jianhu [1 ]
Wu, Jin [2 ]
机构
[1] Shanxi Normal Univ, Coll Food Sci Sci, Taiyuan 030000, Peoples R China
[2] Tianjin Inst Environm & Operat Med, Tianjin Key Lab Risk Assessment & Control Technol, Tianjin 300050, Peoples R China
来源
MOLECULES | 2023年 / 28卷 / 14期
关键词
Cu-based metal-organic framework; liquid chromatography-tandem mass spectrometry; sampling preparation technique; solid-phase extraction; lincomycin; EXTRACTION; NANOPARTICLES;
D O I
10.3390/molecules28145307
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Antibiotic drug residues can adversely affect the human body. Lincomycin is a common veterinary drug that can form residues in foods of animal origin. However, the detection of trace residue levels of lincomycin residues in real samples is challenging. Here, a simple solid phase extraction (SPE) method was developed for the enrichment of lincomycin from cow milk samples before its detection by high-performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS). The adsorbent used in the SPE was a Cu-based metal-organic framework (Cu-MOF) prepared by the solvothermal synthesis approach. The prepared MOFs were characterized using scanning electron microscopy (SEM), Fourier-transform infrared spectroscopy (FT-IR), X-ray diffractometry (XRD), differential thermogravimetric analysis (TG-DTA), and N2 adsorption-desorption experiments. The adsorption capacity (adsorption equilibrium, extraction time, pH), and elution solvent parameters were investigated. Under the optimized conditions of the HPLC-MS/MS method, lincomycin was detected in the linear range of 10-200 g/L with a detection limit of 0.013 ng/mL. Commercial milk samples were spiked with lincomycin, and a recovery rate between 92.3% and 97.2% was achieved. Therefore, the current method can be successfully applied for the enrichment and determination of lincomycin from milk samples.
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页数:13
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