A Novel Approach to a-Arylacetonitrile Skeletons via para-Selective Alkylation of Protected Anilines

被引：7

作者：

Deng, Zefeng ^{[1
]}

Fan, Weitai ^{[1
]}

Liu, Jian ^{[1
]}

Tu, Guangliang ^{[1
]}

Huang, Pengcheng ^{[1
]}

Xu, Xu ^{[1
]}

Tan, Jie ^{[1
]}

Ji, Shun-Jun ^{[1
]}

Zhao, Yingsheng ^{[1
,2
,3
]}

机构：

[1] Soochow Univ, Coll Chem Chem Engn & Mat Sci, Key Lab Organ Synth Jiangsu Prov, Suzhou 215123, Peoples R China

[2] Henan Normal Univ, Sch Chem & Chem Engn, Xinxiang 453000, Peoples R China

[3] Suzhou Key Lab Novel Semicond Optoelect Mat & Devi, Suzhou, Peoples R China

来源：

CHEMISTRY-A EUROPEAN JOURNAL | 2023年 / 29卷 / 44期

关键词：

Aniline; & alpha; -arylacetonitrile skeletons; para-selectivity; ruthenium catalyst; C-H DIFLUOROMETHYLATION; META; ARENES; BROMINATION; NITRILES;

D O I：

10.1002/chem.202300905

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A ruthenium-catalyzed para-selective alkylation of protected anilines to construct a-arylacetonitrile skeletons has been reported. We firstly disclosed the ethyl 2-bromo-2-cyanopropanoate was an effective alkylating reagent in ruthenmuim-catalyzed remote-selective C-H functionalization. A wide variety of a-arylacetonitrile skeletons can be directly obtained with moderate to good yields. Importantly, the products contain both nitrile and ester groups guaranteeing its direct transformation into other useful synthetic units, indicating the synthetic importance of this method.

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页数：5

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