Breakthrough treatments for accelerated wound healing

被引：216

作者：

Freedman, Benjamin R. ^{[1
,2
,3
]}

Hwang, Charles ^{[4
]}

Talbot, Simon ^{[4
]}

Hibler, Brian ^{[5
]}

Matoori, Simon ^{[1
,2
,6
]}

Mooney, David J. ^{[1
,2
]}

机构：

[1] Harvard Univ, John A Paulson Sch Engn & Appl Sci, Cambridge, MA 02138 USA

[2] Harvard Univ, Wyss Inst Biol Inspired Engn, Boston, MA 02138 USA

[3] Beth Israel Deaconess Med Ctr, Dept Orthopaed Surg, Boston, MA 02215 USA

[4] Harvard Univ, Brigham & Womens Hosp, Div Plast Surg, Boston, MA USA

[5] Schweiger Dermatol Grp, New York, NY USA

[6] Univ Montreal, Dept Pharm, Montreal, PQ, Canada

来源：

SCIENCE ADVANCES | 2023年 / 9卷 / 20期

关键词：

PRESSURE ULCERS; DRUG-DELIVERY; SUSTAINED-RELEASE; CELL-DEATH; TENDON; CLOSURE; ALIGNMENT; MODELS; INFLAMMATION; DEBRIDEMENT;

D O I：

10.1126/sciadv.ade7007

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Skin injuries across the body continue to disrupt everyday life for millions of patients and result in prolonged hospital stays, infection, and death. Advances in wound healing devices have improved clinical practice but have mainly focused on treating macroscale healing versus underlying microscale pathophysiology. Consensus is lacking on optimal treatment strategies using a spectrum of wound healing products, which has motivated the design of new therapies. We summarize advances in the development of novel drug, biologic products, and biomaterial therapies for wound healing for marketed therapies and those in clinical trials. We also share perspectives for successful and accelerated translation of novel integrated therapies for wound healing.

引用

页数：11

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