The Roles of Extracellular Vesicles in the Progression of Renal Cell Carcinoma and Their Potential for Future Clinical Application

被引：3

作者：

Takeda, Masashi ^{[1
]}

Akamatsu, Shusuke ^{[2
]}

Kita, Yuki ^{[1
]}

Goto, Takayuki ^{[1
]}

Kobayashi, Takashi ^{[1
]}

机构：

[1] Kyoto Univ, Grad Sch Med, Dept Urol, Kyoto 6068507, Japan

[2] Nagoya Univ, Grad Sch Med, Dept Urol, Nagoya 4668550, Japan

来源：

NANOMATERIALS | 2023年 / 13卷 / 10期

关键词：

extracellular vesicle; renal cell carcinoma; biomarker; therapeutics; cancer progression; DENSITY-GRADIENT SEPARATION; TUMOR PROGRESSION; MEMBRANE-VESICLES; MEDIATED TRANSFER; EXOSOME ISOLATION; CANCER EXOSOMES; EMERGING ROLE; PHASE-III; IN-VITRO; MICROVESICLES;

D O I：

10.3390/nano13101611

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Renal cell carcinoma (RCC) is the most common type of kidney cancer and is thought to originate from renal tubular epithelial cells. Extracellular vesicles (EVs) are nanosized lipid bilayer vesicles that are secreted into extracellular spaces by nearly all cell types, including cancer cells and non-cancerous cells. EVs are involved in multiple steps of RCC progression, such as local invasion, host immune modulation, drug resistance, and metastasis. Therefore, EVs secreted from RCC are attracting rapidly increasing attention from researchers. In this review, we highlight the mechanism by which RCC-derived EVs lead to disease progression as well as the potential and challenges related to the clinical implications of EV-based diagnostics and therapeutics.

引用

页数：18

共 50 条

[31] Potential roles of extracellular vesicles in the pathophysiology, diagnosis, and treatment of autoimmune diseases
Tian, Jing
Casella, Giacomo
Zhang, Yuan
Rostami, Abdolmohamad
Li, Xing
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES, 2020, 16 (04): : 620 - 632
[32] The therapeutic potential of mesenchymal stem cell-derived extracellular vesicles
Katsuda, Takeshi
Kosaka, Nobuyoshi
Takeshita, Fumitaka
Ochiya, Takahiro
PROTEOMICS, 2013, 13 (10-11) : 1637 - 1653
[33] The Three-Gene Signature in Urinary Extracellular Vesicles from Patients with Clear Cell Renal Cell Carcinoma
De Palma, Giuseppe
Sallustio, Fabio
Curci, Claudia
Galleggiante, Vanessa
Rutigliano, Monica
Serino, Grazia
Ditonno, Pasquale
Battaglia, Michele
Schena, Francesco P.
JOURNAL OF CANCER, 2016, 7 (14): : 1960 - 1967
[34] Emerging roles of extracellular vesicles in polyglutamine diseases: Mutant protein transmission, therapeutic potential, and diagnostics
Takeuchi, Toshihide
Nagai, Yoshitaka
NEUROCHEMISTRY INTERNATIONAL, 2022, 157
[35] The Emerging Roles and Therapeutic Potential of Extracellular Vesicles in Infertility
Zhou, Guannan
Gu, Yuanyuan
Zhou, Fangyue
Zhang, Menglei
Zhang, Ganrong
Wu, Ligang
Hua, Keqin
Ding, Jingxin
FRONTIERS IN ENDOCRINOLOGY, 2021, 12
[36] Extracellular vesicles in oral squamous cell carcinoma: current progress and future prospect
Zhang, Yanqi
Liu, Jianing
Liu, Shiyu
Yu, Lu
Liu, Siying
Li, Meng
Jin, Fang
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY, 2023, 11
[37] The Role of Epigenetics in the Progression of Clear Cell Renal Cell Carcinoma and the Basis for Future Epigenetic Treatments
Angulo, Javier C.
Manini, Claudia
Lopez, Jose I.
Pueyo, Angel
Colas, Begona
Ropero, Santiago
CANCERS, 2021, 13 (09)
[38] Therapeutic application of extracellular vesicles in acute and chronic renal injury
Rovira, Jordi
Diekmann, Fritz
Campistol, Josep M.
Jose Ramirez-Bajo, Maria
NEFROLOGIA, 2017, 37 (02): : 126 - 137
[39] Guidance on the clinical application of extracellular vesicles
Terai, Shuji
Asonuma, Motohiro
Hoshino, Ayuko
Kino-oka, Masahiro
Ochiya, Takahiro
Okada, Kiyoshi
Sato, Yoji
Takahashi, Yuki
Tobita, Morikuni
Tsuchiya, Atsunori
REGENERATIVE THERAPY, 2025, 29 : 43 - 50
[40] MicroRNAs in extracellular vesicles: A potential role in cancer progression
Parashar, Deepak
Mukherjee, Tanmoy
Gupta, Saurabh
Kumar, Umesh
Das, Kaushik
CELLULAR SIGNALLING, 2024, 121

← 1 2 3 4 5 →