Plasmodium falciparum adapts its investment into replication versus transmission according to the host environment

被引：18

作者：

Abdi, Abdirahman, I ^{[1
,2
]}

Achcar, Fiona ^{[3
,4
]}

Sollelis, Lauriane ^{[3
,4
]}

Silva-Filho, Joao Luiz ^{[3
,4
]}

Mwikali, Kioko ^{[1
]}

Muthui, Michelle ^{[1
]}

Mwangi, Shaban ^{[1
]}

Kimingi, Hannah W. ^{[1
]}

Orindi, Benedict ^{[1
]}

Andisi Kivisi, Cheryl ^{[1
,2
]}

Alkema, Manon ^{[5
]}

Chandrasekar, Amrita ^{[3
]}

Bull, Peter C. ^{[1
]}

Bejon, Philip ^{[1
]}

Modrzynska, Katarzyna ^{[3
]}

Bousema, Teun ^{[5
]}

Marti, Matthias ^{[3
,4
]}

机构：

[1] KEMRI Wellcome Trust Res Programme, Kilifi, Kenya

[2] Pwani Univ, Biosci Res Ctr, Kilifi, Kenya

[3] Univ Glasgow, Wellcome Ctr Integrat Parasitol, Glasgow, Scotland

[4] Univ Zurich, Inst Parasitol, Vetsuisse & Med Fac, Zurich, Switzerland

[5] Radboud Univ Nijmegen, Med Ctr, Nijmegen, Netherlands

来源：

ELIFE | 2023年 / 12卷

基金：

英国惠康基金; 欧洲研究理事会;

关键词：

malaria; transmission; adaptation; host parasite interaction; Plasmodium falciparum; MASS-SPECTROMETRY DATA; ANTIGENIC VARIATION; SEVERE MALARIA; VAR GENE; EXPRESSION; GAMETOCYTOGENESIS; COMMITMENT; MORBIDITY; PHENOTYPE; PROTEINS;

D O I：

10.7554/eLife.85140

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The malaria parasite life cycle includes asexual replication in human blood, with a proportion of parasites differentiating to gametocytes required for transmission to mosquitoes. Commitment to differentiate into gametocytes, which is marked by activation of the parasite transcription factor ap2-g, is known to be influenced by host factors but a comprehensive model remains uncertain. Here, we analyze data from 828 children in Kilifi, Kenya with severe, uncomplicated, and asymptomatic malaria infection over 18 years of falling malaria transmission. We examine markers of host immunity and metabolism, and markers of parasite growth and transmission investment. We find that inflammatory responses associated with reduced plasma lysophosphatidylcholine levels are associated with markers of increased investment in parasite sexual reproduction (i.e. transmission investment) and reduced growth (i.e. asexual replication). This association becomes stronger with falling transmission and suggests that parasites can rapidly respond to the within-host environment, which in turn is subject to changing transmission.

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