Associations of life course obesity with endometrial cancer in the Epidemiology of Endometrial Cancer Consortium (E2C2)

被引：23

作者：

Harvey, Summer, V ^{[1
,26
]}

Wentzensen, Nicolas ^{[1
]}

Bertrand, Kimberly ^{[2
]}

Black, Amanda ^{[1
]}

Brinton, Louise A. ^{[1
]}

Chen, Chu ^{[3
]}

Costas, Laura ^{[4
,5
]}

Dal Maso, Luigino ^{[6
]}

De Vivo, Immaculata ^{[7
,8
]}

Du, Mengmeng ^{[9
]}

Garcia-Closas, Montserrat ^{[1
]}

Goodman, Marc T. ^{[10
,11
]}

Gorzelitz, Jessica ^{[12
]}

Johnson, Lisa ^{[3
]}

Lacey, James, V ^{[13
]}

Liao, Linda ^{[12
]}

Lipworth, Loren ^{[14
]}

Lissowska, Jolanta ^{[15
]}

Miller, Anthony B. ^{[16
]}

O'Connell, Kelli ^{[9
]}

O'Mara, Tracy A. ^{[17
]}

Ou, Xiao ^{[14
]}

Palmer, Julie R. ^{[2
]}

Patel, Alpa, V ^{[18
]}

Paytubi, Sonia ^{[4
]}

Pelegrina, Beatriz ^{[4
,5
]}

Petruzella, Stacey ^{[9
]}

Prizment, Anna ^{[19
]}

Rohan, Thomas ^{[20
]}

Sandin, Sven ^{[21
]}

Setiawan, Veronica Wendy ^{[22
]}

Sinha, Rashmi

Trabert, Britton ^{[1
]}

Webb, Penelope M. ^{[23
]}

Wilkens, Lynne R. ^{[24
]}

Xu, Wanghong ^{[25
]}

Yang, Hannah P. ^{[1
]}

Zheng, Wei ^{[14
]}

Clarke, Megan A. ^{[1
]}

机构：

[1] NCI, Div Canc Epidemiol & Genet, Rockville, MD USA

[2] Boston Univ, Slone Epidemiol Ctr, Boston, MA USA

[3] Fred Hutchinson Canc Ctr, Div Publ Hlth Sci, Seattle, WA USA

[4] Catalan Inst Oncol, Canc Epidemiol Res Programme IDIBELL, Barcelona, Spain

[5] Consortium Biomed Res Epidemiol & Publ Hlth CIBERE, Madrid, Spain

[6] Ctr Riferimento Oncol, Canc Epidemiol Unit, Aviano, Italy

[7] Brigham & Womens Hosp, Dept Med, Channing Div Network Med, Channing Div Network Med, Boston, MA USA

[8] Harvard Med Sch, Boston, MA USA

[9] Mem Sloan Kettering Canc Ctr, Dept Epidemiol & Biostat, New York, NY USA

[10] Cedars Sinai Canc, Los Angeles, CA USA

[11] Cedars Sinai Med Ctr, Dept Med, Los Angeles, CA USA

[12] NCI, Div Canc Epidemiol & Genet, Metab Epidemiol Branch, Bethesda, MD USA

[13] Beckman Res Inst, City Hope Natl Med Ctr, Dept Comp & Quantitat Med, Div Hlth Analyt, Duarte, CA USA

[14] Vanderbilt Univ Sch Med, Vanderbilt Ingram Canc Ctr, Dept Med, Div Epidemiol, Nashville, TN USA

[15] M Sklodowska Curie Natl Res Inst Oncol, Dept Canc Epidemiol & Prevent, Warsaw, Poland

[16] Univ Toronto, Dalla Lana Sch Publ Hlth, Toronto, ON, Canada

[17] QIMR Berghofer Med Res Inst, Canc Res Program, Brisbane, Qld, Australia

[18] Amer Canc Soc, Dept Populat Sci, Atlanta, GA USA

[19] Univ Minnesota, Div Hematol Oncol & Transplantat, Minneapolis, MN USA

[20] Albert Einstein Coll Med, Dept Epidemiol & Populat Hlth, Bronx, NY USA

[21] Karolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden

[22] Univ Southern Calif, Keck Sch Med, Dept Populat & Publ Hlth Sci, Los Angeles, CA USA

[23] QIMR Berghofer Med Res Inst, Populat Hlth Dept, Brisbane, Qld, Australia

[24] Univ Hawaii, Canc Ctr, Epidemiol Program, Honolulu, HI USA

[25] Fudan Univ, Sch Publ Hlth, Dept Epidemiol, Shanghai, Peoples R China

[26] NCI, Div Canc Epidemiol & Genet, 9609 Med Ctr Dr, Rockville, MD 20850 USA

来源：

INTERNATIONAL JOURNAL OF EPIDEMIOLOGY | 2023年 / 52卷 / 04期

基金：

美国国家卫生研究院; 瑞典研究理事会; 英国医学研究理事会;

关键词：

Endometrial cancer; gynaecology; epidemiology; uterine cancer; obesity; life course exposures; BMI; weight change; weight loss; BMI change; BODY-MASS INDEX; NIH-AARP DIET; WEIGHT-GAIN; RISK; SIZE; WOMEN; HORMONES; OVERWEIGHT; MORTALITY; ADULTHOOD;

D O I：

10.1093/ije/dyad046

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

Background Adult obesity is a strong risk factor for endometrial cancer (EC); however, associations of early life obesity with EC are inconclusive. We evaluated associations of young adulthood (18-21 years) and adulthood (at enrolment) body mass index (BMI) and weight change with EC risk in the Epidemiology of Endometrial Cancer Consortium (E2C2). Methods We pooled data from nine case-control and 11 cohort studies in E2C2. We performed multivariable logistic regression analyses to estimate odds ratios (OR) and 95% confidence intervals (95% CI) for BMI (kg/m(2)) in young adulthood and adulthood, with adjustment for BMI in adulthood and young adulthood, respectively. We evaluated categorical changes in weight (5-kg increments) and BMI from young adulthood to adulthood, and stratified analyses by histology, menopausal status, race and ethnicity, hormone replacement therapy (HRT) use and diabetes. Results We included 14 859 cases and 40 859 controls. Obesity in adulthood (OR = 2.85, 95% CI = 2.47-3.29) and young adulthood (OR = 1.26, 95% CI = 1.06-1.50) were positively associated with EC risk. Weight gain and BMI gain were positively associated with EC; weight loss was inversely associated with EC. Young adulthood obesity was more strongly associated with EC among cases diagnosed with endometrioid histology, those who were pre/perimenopausal, non-Hispanic White and non-Hispanic Black, among never HRT users and non-diabetics. Conclusions Young adulthood obesity is associated with EC risk, even after accounting for BMI in adulthood. Weight gain is also associated with EC risk, whereas weight loss is inversely associated. Achieving and maintaining a healthy weight over the life course is important for EC prevention efforts.

引用

页码：1086 / 1099

页数：14

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