Antiviral effects of Atractyloside A on the influenza B virus (Victoria strain) infection

被引：4

作者：

Han, Jicheng ^{[1
,2
]}

Zhu, Xiangyu ^{[1
,3
]}

Gao, Zihan ^{[1
,2
]}

Xiao, Yan ^{[1
,2
]}

Zhang, Jinxin ^{[1
,2
]}

Wang, Peng ^{[1
,3
]}

Fang, Jinbo ^{[2
]}

Li, Yiquan ^{[2
]}

Zhu, Yilong ^{[2
]}

Li, Yue ^{[1
,2
]}

Jin, Ningyi ^{[1
,2
]}

Lu, Huijun ^{[1
]}

Lin, Dazhuan ^{[4
]}

Liu, Wenshen ^{[1
]}

机构：

[1] Chinese Acad Agr Sci, Changchun Vet Res Inst, Changchun, Peoples R China

[2] Changchun Univ Chinese Med, Academician Workstat, Changchun, Peoples R China

[3] Jilin Agr Univ, Coll Anim Sci & Technol, Changchun, Peoples R China

[4] Changchun Med Coll, Coll Pharmaceut & Food, Changchun, Peoples R China

来源：

FRONTIERS IN MICROBIOLOGY | 2023年 / 13卷

基金：

中国博士后科学基金;

关键词：

Atractyloside A; antiviral drugs; macrophage polarization; influenza virus; influenza B virus (IBV); VACCINE EFFECTIVENESS; STRATEGIES; EVOLUTION; ECOLOGY;

D O I：

10.3389/fmicb.2022.1067725

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Influenza viruses pose a serious threat to human health, infecting hundreds of millions of people worldwide each year, resulting in a significant increase in global morbidity and mortality. Influenza activity has declined at the onset of the COVID-19 pandemic, but the genetic diversity of B/Victoria lineage viruses has increased significantly during this period. Therefore, the prevention and treatment of the influenza B Victoria strain virus should continue to attract research attention. In this study, we found that Atractyloside A (AA), one of the effective components in Atractylodes lancea (Thunb.) DC shows potential antiviral properties. This study shows that AA not only possesses anti-influenza B virus infection effects in vivo and in vitro but also can regulate macrophage polarization to the M2 type, which can effectively attenuate the damage caused by influenza B virus infection. Therefore, Atractyloside A may be an effective natural drug against B/Victoria influenza infection.

引用

页数：12

共 28 条

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