Advances in mesenchymal stem cells therapy for tendinopathies

被引：3
作者：
Mao, Xu-Feng [1 ]
Zhang, Xi-Qian [1 ]
Yao, Zhe-Yu [1 ]
Mao, Hai-Jiao [1 ]
机构：
[1] Ningbo Univ, Dept Orthopaed Surg, Affiliated Hosp 1, Ningbo 315010, Zhejiang, Peoples R China
来源：
CHINESE JOURNAL OF TRAUMATOLOGY | 2024年 / 27卷 / 01期
关键词：
Mesenchymal stem cells; Tendinopathy; Immunomodulation; Treatment; Review; PLATELET-RICH PLASMA; MARROW STROMAL CELLS; BONE-MARROW; TGF-BETA; MACROPHAGES; INFLAMMATION; DISEASE; PROLIFERATION; PATHOGENESIS; MODULATE;
D O I：
10.1016/j.cjtee.2023.11.002
中图分类号：
R826.8 [整形外科学]; R782.2 [口腔颌面部整形外科学]; R726.2 [小儿整形外科学]; R62 [整形外科学（修复外科学）];
学科分类号：
摘要：
Tendinopathies are chronic diseases of an unknown etiology and associated with inflammation. Mesenchymal stem cells (MSCs) have emerged as a viable therapeutic option to combat the pathological progression of tendinopathies, not only because of their potential for multidirectional differentiation and self -renewal, but also their excellent immunomodulatory properties. The immunomodulatory effects of MSCs are increasingly being recognized as playing a crucial role in the treatment of tendinopathies, with MSCs being pivotal in regulating the inflammatory microenvironment by modulating the immune response, ultimately contributing to improved tissue repair. This review will discuss the current knowledge regarding the application of MSCs in tendinopathy treatments through the modulation of the immune response. (c) 2023 Chinese Medical Association. Production and hosting by Elsevier B.V. This is an open access article under the CC BY -NC -ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
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页码：11 / 17
页数：7
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