Interleukin-6 and-27 as potential novel biomarkers for human pleural tuberculosis regardless of the immunological status

被引：4

作者：

Antas, Paulo ^{[1
,5
]}

Borchert, Juliana ^{[1
]}

Ponte, Carlos ^{[1
]}

Lima, Jessica ^{[1
]}

Georg, Ingebourg ^{[2
]}

Bastos, Mayara ^{[3
]}

Trajman, Anete ^{[3
,4
]}

机构：

[1] Fiocruz MS, Oswaldo Cruz Inst, Rio De Janeiro, Brazil

[2] Evandro Chagas Natl Inst Infect Dis, FIOCRUZ, Rio De Janeiro, Brazil

[3] McGill Univ, Montreal, PQ, Canada

[4] Univ Fed Rio de Janeiro, Rio De Janeiro, Brazil

[5] Fiocruz MS, Oswaldo Cruz Inst, Ave Brasil 4365, BR-21045900 Rio De Janeiro, RJ, Brazil

来源：

MICROBES AND INFECTION | 2024年 / 26卷 / 1-2期

关键词：

Tuberculosis; Pleural; HIV; Human; Cytokine; INTERFERON-GAMMA; DIAGNOSTIC-VALUE; EFFUSION; MARKERS;

D O I：

10.1016/j.micinf.2023.105238

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Tuberculosis (TB) is the leading cause of pleural exudative effusions. Inflammatory markers, such as IFNy and ADA, have been used as proxies for its diagnosis. We evaluated ex vivo levels of several cytokines in 83 pleural effusion specimens from patients with TB (including 10 with HIV co-infection) and 26 patients with other pleuritis using multiplex and ELISA assays. IL-6 and IL-27 levels were higher (p < 0.04) in TB patients, regardless of the HIV status and the approach. IL-2, IL-4, IL-8, IFNy, TNF and G-CSF showed variable results depending on the assay. This warranty these markers to be further validated. (c) 2023 The Authors. Published by Elsevier Masson SAS on behalf of Institut Pasteur. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

引用

页数：6

共 34 条

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