Implantable bioelectronic systems for early detection of kidney transplant rejection

被引：64

作者：

Madhvapathy, Surabhi R. ^{[1
,2
]}

Wang, Jiao-Jing ^{[3
]}

Wang, Heling ^{[4
,5
,6
]}

Patel, Manish ^{[2
,7
]}

Chang, Anthony ^{[8
]}

Zheng, Xin ^{[3
]}

Huang, Yonggang ^{[4
,5
]}

Zhang, Zheng J. ^{[3
,9
,10
]}

Gallon, Lorenzo ^{[3
,11
]}

Rogers, John A. ^{[1
,2
,12
,13
]}

机构：

[1] Northwestern Univ, Dept Mat Sci & Engn, Evanston, IL 60208 USA

[2] Northwestern Univ, Querrey Simpson Inst Bioelectron, Evanston, IL 60208 USA

[3] Northwestern Univ, Comprehens Transplant Ctr, Chicago, IL 60611 USA

[4] Northwestern Univ, Dept Mech Engn, Evanston, IL 60208 USA

[5] Northwestern Univ, Dept Civil Engn, Evanston, IL 60208 USA

[6] Tsinghua Univ, Lab Flexible Elect Technol, Beijing 100085, Peoples R China

[7] Univ Illinois, Dept Intervent Radiol, Chicago, IL 60612 USA

[8] Univ Chicago, Dept Pathol, Chicago, IL 60637 USA

[9] Northwestern Univ, Dept Surg, Feinberg Sch Med, Chicago, IL 60611 USA

[10] Northwestern Univ, Simpson Querrey Inst BioNanotechnol, Chicago, IL 60611 USA

[11] Northwestern Univ, Dept Nephrol, Chicago, IL 60611 USA

[12] Northwestern Univ, Dept Biomed Engn, Evanston, IL 60208 USA

[13] Northwestern Univ, Dept Neurol Surg, Chicago, IL 60611 USA

来源：

SCIENCE | 2023年 / 381卷 / 6662期

关键词：

TEMPERATURE;

D O I：

10.1126/science.adh7726

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Early-stage organ transplant rejection can be difficult to detect. Percutaneous biopsies occur infrequently and are risky, and measuring biomarker levels in blood can lead to false-negative and -positive outcomes. We developed an implantable bioelectronic system capable of continuous, real-time, long-term monitoring of the local temperature and thermal conductivity of a kidney for detecting inflammatory processes associated with graft rejection, as demonstrated in rat models. The system detects ultradian rhythms, disruption of the circadian cycle, and/or a rise in kidney temperature. These provide warning signs of acute kidney transplant rejection that precede changes in blood serum creatinine/urea nitrogen by 2 to 3 weeks and approximately 3 days for cases of discontinued and absent administration of immunosuppressive therapy, respectively.

引用

页码：1105 / 1112

页数：8

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