Renal dysfunction and outcome in left ventricular non-compaction

被引:0
作者
Erhart, Ladina [1 ]
Kaufmann, Beat A. [2 ]
Gencer, Baris [3 ,4 ]
Haager, Philipp K. [5 ]
Mulller, Hajo [3 ]
Kobza, Richard [6 ]
Held, Leonhard [7 ]
Staempfli, Simon F. [1 ,6 ,8 ]
机构
[1] Univ Heart Ctr Zurich, Dept Cardiol, Zurich, Switzerland
[2] Univ Hosp Basel, Dept Cardiol, Basel, Switzerland
[3] Univ Hosp Geneva, Div Cardiol, Geneva, Switzerland
[4] Univ Bern, Inst Primary Hlth Care BIHAM, Bern, Switzerland
[5] Cantonal Hosp St Gallen, Div Cardiol, St Gallen, Switzerland
[6] Luzerner Kantonsspital, Dept Cardiol, Heart Ctr Lucerne, Luzern, Switzerland
[7] Univ Zurich, Epidemiol Biostat & Prevent Inst, Dept Biostat, Zurich, Switzerland
[8] Luzerner Kantonsspital, Heart Ctr Lucerne, Outpatient Clin & Echocardiog, Spitalstr, CH-6000 Luzern, Switzerland
关键词
renal function; kidney; urea; estimated glomerular filtration rate; creatinine; prognosis; heart failure; LINEAR-REGRESSION PROCEDURES; GLOMERULAR-FILTRATION-RATE; HEART-FAILURE; PREDICTORS; NONCOMPACTION; EPIDEMIOLOGY; MYOCARDIUM; ADULTS; CARDIOMYOPATHY; IMPAIRMENT;
D O I
10.5603/CJ.a2022.0105
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Background: While renal function has been observed to inversely correlate with clinical outcome in other cardiomyopathies, its prognostic significance in patients with left ventricular non-compaction cardiomyopathy (LVNC) has not been investigated. The aim of this study was to determine the prognostic value of renal function in LVNC patients. Methods: Patients with isolated LVNC as diagnosed by echocardiography and/or magnetic resonance imaging in 4 Swiss centers were retrospectively analyzed for this study. Values for creatinine, urea, and estimated glomerular filtration rate (eGFR) as assessed by the CKD-EPI 2009 formula were collected and analyzed by a Cox regression model for the occurrence of a composite endpoint (death or heart transplantation). Results: During the median observation period of 7.4 years 23 patients reached the endpoint. The age- and gender-corrected hazard ratios (HR) for death or heart transplantation were: 1.9 (95% confidence interval [CI] 1.4-2.6) for each increase over baseline creatinine level of 30 mu mol/L (p < 0.001), 1.6 (95% CI 1.2-2.2) for each increase over baseline urea level of 5 mmol/L (p = 0.004), and 3.6 (95% CI 1.9-6.9) for each decrease below baseline eGFR level of 30 mL/min (p <= 0.001). The HR (log2) for every doubling of creatinine was 7.7 (95% CI 3-19.8; p < 0.001), for every doubling of urea 2.5 (95% CI 1.5-4.3; p < 0.001), and for every bisection of eGFR 5.3 (95% CI 2.4-11.6; p < 0.001). Conclusions: This study provides evidence that in patients with LVNC impairment in renal function is associated with an increased risk of death and heart transplantation suggesting that kidney function assessment should be standard in risk assessment of LVNC patients.
引用
收藏
页码:781 / 789
页数:9
相关论文
共 40 条
[21]   A New Equation to Estimate Glomerular Filtration Rate [J].
Levey, Andrew S. ;
Stevens, Lesley A. ;
Schmid, Christopher H. ;
Zhang, Yaping ;
Castro, Alejandro F., III ;
Feldman, Harold I. ;
Kusek, John W. ;
Eggers, Paul ;
Van Lente, Frederick ;
Greene, Tom ;
Coresh, Josef .
ANNALS OF INTERNAL MEDICINE, 2009, 150 (09) :604-612
[22]   Complications of non-compaction of the left ventricular myocardium in a paediatric population:: a prospective study [J].
Lilje, Christian ;
Razek, Vit ;
Joyce, James J. ;
Rau, Thomas ;
Finckh, Barbara F. ;
Weiss, Florian ;
Habermann, Christian R. ;
Rice, Janet C. ;
Weil, Jochen .
EUROPEAN HEART JOURNAL, 2006, 27 (15) :1855-1860
[23]   Contemporary definitions and classification of the cardiomyopathies - An American Heart Association Scientific Statement from the Council on Clinical Cardiology, Heart Failure and Transplantation Committee; Quality of Care and Outcomes Research and Functional Genomics and Translational Biology Interdisciplinary Working Groups; And Council on Epidemiology and Prevention [J].
Maron, BJ ;
Towbin, JA ;
Thiene, G ;
Antzelevitch, C ;
Corrado, D ;
Arnett, D ;
Moss, AJ ;
Seidman, CE ;
Young, JB .
CIRCULATION, 2006, 113 (14) :1807-1816
[24]   Natural history and familial characteristics of isolated left ventricular non-compaction [J].
Murphy, RT ;
Thaman, R ;
Blanes, JG ;
Ward, D ;
Sevdalis, E ;
Papra, E ;
Kiotsekolglou, A ;
Tome, MT ;
Pellerin, D ;
McKenna, WJ ;
Elliott, PM .
EUROPEAN HEART JOURNAL, 2005, 26 (02) :187-192
[25]   Long-term follow-up of 34 adults with isolated left ventricular noncompaction: A distinct cardiomyopathy with poor prognosis [J].
Oechslin, EN ;
Jost, CHA ;
Rojas, JR ;
Kaufmann, PA ;
Jenni, R .
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2000, 36 (02) :493-+
[26]  
PACKER M, 1986, CIRCULATION, V74, P766, DOI 10.1161/01.CIR.74.4.766
[27]  
PASSING H, 1984, J CLIN CHEM CLIN BIO, V22, P431
[28]  
PASSING H, 1983, J CLIN CHEM CLIN BIO, V21, P709
[29]   Isolated noncompaction of the myocardium in adults [J].
Ritter, M ;
Oechslin, E ;
Sutsch, G ;
Attenhofer, C ;
Schneider, J ;
Jenni, R .
MAYO CLINIC PROCEEDINGS, 1997, 72 (01) :26-31
[30]   Renal function: The Cinderella of cardiovascular risk profile [J].
Ruilope, LM ;
van Veldhuisen, DJ ;
Ritz, E ;
Luscher, TF .
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2001, 38 (07) :1782-1787