共 40 条
IL-6 and IL-27 play both distinct and redundant roles in regulating CD4 T-cell responses during chronic viral infection
被引:3
|作者:
Harker, James A.
[1
,2
]
Greene, Trever T.
[1
]
Barnett, Burton E.
[1
]
Bao, Phuc
[1
]
Dolgoter, Aleksandr
[1
]
Zuniga, Elina I.
[1
]
机构:
[1] Univ Calif San Diego, Dept Biol Sci, Div Mol Biol, La Jolla, CA 92161 USA
[2] Imperial Coll London, Natl Heart & Lung Inst, London, England
来源:
FRONTIERS IN IMMUNOLOGY
|
2023年
/
14卷
基金:
英国惠康基金;
美国国家卫生研究院;
关键词:
chronic viral infection;
lcmv;
IL-6;
IL-27;
T follicular helper cells;
FOLLICULAR HELPER;
STAT3;
DIFFERENTIATION;
MODULATION;
EXPRESSION;
BLOCKADE;
D O I:
10.3389/fimmu.2023.1221562
中图分类号:
R392 [医学免疫学];
Q939.91 [免疫学];
学科分类号:
100102 ;
摘要:
The IL-6 cytokine family signals through the common signal transduction molecule gp130 combined with a cytokine-specific receptor. Gp130 signaling on CD4 T cells is vital in controlling chronic infection of mice with lymphocytic choriomeningitis virus clone 13 (LCMV Cl13), but the precise role of individual members of the IL-6 cytokine family is not fully understood. Transcriptional analysis highlighted the importance of gp130 signaling in promoting key processes in CD4 T cells after LCMV Cl13 infection, particularly genes associated with T follicular helper (Tfh) cell differentiation and IL-21 production. Further, Il27r(-/-)Il6ra(-/-) mice failed to generate antibody or CD8 T-cell immunity and to control LCMV Cl13. Transcriptomics and phenotypic analyses of Il27r(-/-)Il6ra(-/-) Tfh cells revealed that IL-6R and IL-27R signaling was required to activate key pathways within CD4 T cells. IL-6 and IL-27 signaling has distinct and overlapping roles, with IL-6 regulating Tfh differentiation, IL-27 regulating CD4 T cell survival, and both redundantly promoting IL-21.
引用
收藏
页数:11
相关论文