Emerging role of interactions between tumor angiogenesis and cancer stem cells

被引:16
作者
Lv, Shuai [1 ,2 ]
Liu, Yufei [1 ,2 ]
Xie, Changheng [1 ,2 ]
Xue, Chenyang [1 ,2 ]
Du, Shi [3 ]
Yao, Jing [1 ,2 ]
机构
[1] China Pharmaceut Univ, Dept Pharmaceut, State Key Lab Nat Med, 24 Tongjiaxiang, Nanjing 210009, Peoples R China
[2] China Pharmaceut Univ, Dept Pharmaceut, Jiangsu Key Lab Druggabil Biopharmaceut, 24 Tongjiaxiang, Nanjing 210009, Peoples R China
[3] Ohio State Univ, Coll Pharm, Div Pharmaceut & Pharmacol, Columbus, OH 43210 USA
关键词
Cancer stem cell; Tumor angiogenesis; CSCs-angiogenesis vicious circle; HYPOXIA-INDUCIBLE FACTORS; ACUTE MYELOID-LEUKEMIA; SIGNALING PATHWAYS; ENDOTHELIAL-CELLS; INITIATING CELLS; SELF-RENEWAL; PERIVASCULAR NICHE; DRUG-DELIVERY; IN-VIVO; BREAST;
D O I
10.1016/j.jconrel.2023.06.036
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
Tumor angiogenesis and cancer stem cells (CSCs) are two major hallmarks of solid tumors. They have long received attention for their critical roles in tumor progression, metastasis and recurrence. Meanwhile, plenty of evidence indicates the close association between CSCs and tumor vasculature. CSCs are proven to promote tumor angiogenesis, and the highly vascularized tumor microenvironment further maintains CSCs growth in return, thereby forming a hard-breaking vicious circle to promote tumor development. Hence, though monotherapy targeting tumor vasculature or CSCs has been extensively studied over the past decades, the poor prognosis has been limiting the clinical application. This review summarizes the crosstalk between tumor vasculature and CSCs with emphasis on small-molecule compounds and the associated biological signaling pathways. We also highlight the importance of linking tumor vessels to CSCs to disrupt the CSCs-angiogenesis vicious circle. More precise treatment regimens targeting tumor vasculature and CSCs are expected to benefit future tumor treatment development.
引用
收藏
页码:468 / 481
页数:14
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