Synthesis of N-aryl derived formamides using triflic anhydride

被引：2
作者：
Bharamawadeyar, Swetha [1 ]
Sureshbabu, Vommina V. [1 ]
机构：
[1] Bangalore Univ, Dept Chem, Peptide Res Lab, Jnana Bharathi Campus, Bangalore 560056, India
来源：
INDIAN JOURNAL OF CHEMISTRY | 2023年 / 62卷 / 06期
关键词：
N-Formylation; Activating agent; Triflic anhydride; FORMYLATION; AMINES; AMINOCARBONYLATION; ISONITRILES; DERIVATIVES; ACCESS; AMIDES; ACIDS;
D O I：
10.56042/ijc.v62i6.2569
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A facile and convenient one-pot protocol for the N-formylation of aryl amines has been furnished using Tf2O. This approach involves N-formylation of anilines and its derivatives employing formic acid as a formyl source and triflic anhydride (Tf2O) as an activator as the key step. This work highlights the ability of Tf2O as an activating agent, includes operational simplicity, easy applicability to gram-scale preparation and to afford the N-formyl aryl amines in moderate to good yields.
引用
收藏
页码：656 / 661
页数：6
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