Online pharmaceutical process analysis of Chinese medicine using a miniature mass spectrometer: Extraction of active ingredients as an example

被引：11
作者：
Hu, Wangmin [1 ]
Hou, Junling [1 ]
Liu, Wenjing [2 ]
Gu, Xuan [3 ]
Yang, Yulei [1 ]
Shang, Hongcai [2 ]
Zhang, Mei [1 ]
机构：
[1] Beijing Univ Chinese Med, Sch Chinese Mat Med, Beijing 102488, Peoples R China
[2] Beijing Univ Chinese Med, Dongzhimen Hosp, Key Lab Chinese Internal Med, Minist Educ & Beijing, Beijing 100700, Peoples R China
[3] Huayi Pharmaceut Co Ltd, Beijing 102600, Peoples R China
来源：
JOURNAL OF PHARMACEUTICAL ANALYSIS | 2023年 / 13卷 / 05期
基金：
中国国家自然科学基金; 北京市自然科学基金;
关键词：
Process analytical technology; TCM Pharmaceuticals; Miniature mass spectrometry; Online analysis; LATERALIS-RADIX-PRAEPARATA; ELECTROSPRAY-IONIZATION; AMBIENT IONIZATION; PAPER SPRAY; DESIGN;
D O I：
10.1016/j.jpha.2023.03.005
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The automation of traditional Chinese medicine (TCM) pharmaceuticals has driven the development of process analysis from offline to online. Most of common online process analytical technologies are based on spectroscopy, making the identification and quantification of specific ingredients still a challenge. Herein, we developed a quality control (QC) system for monitoring TCM pharmaceuticals based on paper spray ionization miniature mass spectrometry (mini-MS). It enabled real-time online qualitative and quantitative detection of target ingredients in herbal extracts using mini-MS without chromatographic separation for the first time. Dynamic changes of alkaloids in Aconiti Lateralis Radix Praeparata (Fuzi) during decoction were used as examples, and the scientific principle of Fuzi compatibility was also investigated. Finally, the system was verified to work stably at the hourly level for pilot-scale extraction. This mini-MS based online analytical system is expected to be further developed for QC applications in a wider range of pharmaceutical processes.(c) 2023 The Authors. Published by Elsevier B.V. on behalf of Xi'an Jiaotong University. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
引用
收藏
页码：535 / 543
页数：9
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