Delivery Systems in Ocular Retinopathies: The Promising Future of Intravitreal Hydrogels as Sustained-Release Scaffolds

被引：14

作者：

Rafael, Diana ^{[1
,2
,3
]}

Guerrero, Marcelo ^{[4
,5
]}

Marican, Adolfo ^{[4
,5
,6
]}

Arango, Diego ^{[7
,8
]}

Sarmento, Bruno ^{[9
]}

Ferrer, Roser ^{[10
]}

Duran-Lara, Esteban F. ^{[4
,5
]}

Clark, Simon J. ^{[11
,12
,13
]}

Schwartz, Simo, Jr. ^{[1
,10
]}

机构：

[1] Univ Autonoma Barcelona UAB, Vall Hebron Inst Recerca VHIR, Drug Delivery & Targeting, Barcelona 08035, Spain

[2] Inst Salud Carlos III, Ctr Invest Biomed Red Bioingn Biomat & Nanomed CI, Madrid 28029, Spain

[3] Univ Autonoma Barcelona UAB, Vall Hebron Inst Recerca VHIR, Funct Validat & Preclin Res FVPR, 20 ICTS Nanbiosis, Barcelona 08035, Spain

[4] Univ Talca, Fac Ciencias Salud, Dept Microbiol, Drug Delivery & Controlled Release,Bio & Nano Mat, Talca 3460000, Chile

[5] Univ Talca, Ctr Nanomed Diagnost & Drug Dev ND3, Talca 3460000, Chile

[6] Univ Talca, Inst Quim Recursos Nat, Talca 3460000, Chile

[7] Univ Autonoma Barcelona, Vall Hebron Univ Hosp Res Inst VHIR, Grp Biomed Res Digest Tract Tumors, Barcelona 08035, Spain

[8] Biomed Res Inst Lleida IRBLleida, Grp Mol Oncol, Lleida 25198, Spain

[9] Saude Univ Porto, i3S Inst Invest & Inovacao, Rua Alfredo Allen 208, P-4200135 Porto, Portugal

[10] Vall Hebron Hosp, Clin Biochem Grp, Barcelona 08035, Spain

[11] Eberhard Karls Univ Tubingen, Univ Eye Clin, Dept Ophthalmol, D-72076 Tubingen, Germany

[12] Eberhard Karls Univ Tubingen, Inst Ophthalm Res, D-72076 Tubingen, Germany

[13] Univ Manchester, Lydia Becker Inst Immunol & Inflammat, Fac Biol Med & Hlth, Manchester M13 9PL, England

来源：

PHARMACEUTICS | 2023年 / 15卷 / 05期

关键词：

hydrogels; stimuli-responsive; thermo-responsive; retinopathies; delivery systems; intravitreal delivery; ENDOTHELIAL GROWTH-FACTOR; DIABETIC MACULAR EDEMA; DIELS-ALDER HYDROGELS; REVERSE THERMAL GEL; DRUG-DELIVERY; INTRAOCULAR PHARMACOKINETICS; THERMORESPONSIVE HYDROGELS; POSTERIOR SEGMENT; EXTENDED-RELEASE; PROTEIN RELEASE;

D O I：

10.3390/pharmaceutics15051484

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Slow-release delivery systems are needed to ensure long-term sustained treatments for retinal diseases such as age-related macular degeneration and diabetic retinopathy, which are currently treated with anti-angiogenic agents that require frequent intraocular injections. These can cause serious co-morbidities for the patients and are far from providing the adequate drug/protein release rates and required pharmacokinetics to sustain prolonged efficacy. This review focuses on the use of hydrogels, particularly on temperature-responsive hydrogels as delivery vehicles for the intravitreal injection of retinal therapies, their advantages and disadvantages for intraocular administration, and the current advances in their use to treat retinal diseases.

引用

页数：26

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