Update on Squamous Cell Carcinoma of the Nail Unit: An Human Papillomavirus-Associated Condition

被引：2

作者：

Bray, Eric R. ^{[1
]}

Tosti, Antonella ^{[1
]}

Morrison, Brian W. ^{[1
]}

机构：

[1] Univ Miami, Philip Frost Dept Dermatol & Cutaneous Surg, Miller Sch Med, Miami, FL 33146 USA

来源：

SKIN APPENDAGE DISORDERS | 2024年 / 10卷 / 03期

关键词：

Nail unit squamous cell carcinoma; Bowen's disease; Human papillomavirus; Sexually transmitted disease; Nail tumor; Nail neoplasm; Nail malignancy; Melanonychia; Wart; HPV vaccination; CUTANEOUS HUMAN PAPILLOMAVIRUSES; PERIUNGUAL BOWENS-DISEASE; RISK; VACCINATION; INFECTION; APPARATUS; FINGERS;

D O I：

10.1159/000537760

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

Background: Squamous cell carcinoma (SCC) and SCC in situ (Bowen's disease) are the most common malignancies of the nail unit. They are frequently seen in men over 50 and most commonly affect the fingers. The role of high-risk human papillomavirus (HPV) infection has been identified as a key contributor to the development of nail unit SCC. Summary: In this review, we aimed to summarize the current state of our understanding of how HPV contributes to nail unit SCC, the role of genitodigital transmission of HPV, and the clinical features of HPV-associated nail unit SCC. We also review current advances in the treatment of nail unit SCC, with a focus on the potential role of HPV vaccination in the treatment and prevention of nail unit SCC. Key Messages: Nail unit SCC should be recognized as an HPV-associated disease. HPV vaccination may represent a non-surgical modality for the management of these challenging malignancies in the appropriate clinical setting.

引用

页码：199 / 206

页数：8

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