SYNTHESIS, CHEMICAL CHARACTERIZATION, AND BIOLOGICAL INVESTIGATION OF NATURALLY ISOLATED HESPERIDIN AND ITS METAL COMPLEXES

被引:1
|
作者
Abdelgawad, Ahmed A. M. [1 ,2 ]
El Bassossy, Taha A. I. [1 ]
Ahmed, Fatma A. [1 ]
机构
[1] Desert Res Ctr, Med & Aromat Plants Dept, Cairo 11753, Egypt
[2] Jazan Univ, Coll Sci, Dept Chem, Jizan 45142, Saudi Arabia
关键词
KEY WORDS : Hesperidin; Metal ions; Complexation; Antioxidant; Anti; -Alzheimer; Coagulant activity; ANTIOXIDANT CAPACITY; OXIDATIVE STRESS; FLAVONOIDS; EXTRACT; PLASMA; L;
D O I
10.4314/bcse.v38i2.8
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
This study was conducted to investigate the ability of hesperidin (HES) to form metal-complexes (HES-M) by chelation with transition metals such iron(III), copper(II), zinc(II), and silver(I), in addition to screen the antioxidant activity (DPPH free radical scavenging and phosphomolybdenum reduction potential methods PRP), anti-Alzheimer activity [(acetylcholinesterase (AChE)] inhibition assay) and coagulant activity (prothrombin time PT assay). The results indicated that HES could form a 1:1 complex with the studied metals in methanolic solution. The complex has been synthesized and characterized by physicochemical methods. Complexing of hesperidin with metals leads to increase in the antioxidant activity by 15.4-33%. Also, the total antioxidant capacities of HES-M complexes were increased by 13.8-251%. Cu-complex revealed the most increasing antioxidant activity by 33% for DPPH scavenging activity and 251% for PRP activity. The inhibition capacity of the HES, as well as of the HES-M complexes on the enzyme AChE, was revealed that only HES-Zn complex has higher anti-Alzheimer activity (IC(50 )1.18 mg/mL). HES and HES-M complexes led to accelerate the clotting time by 28.9-67.3%, where HES-Zn complex was the most accelerating clotting time by 67.3%. The high increase in total antioxidant activity of hesperidin after chelating with copper (251%) opens the door for further research.
引用
收藏
页码:385 / 395
页数:11
相关论文
共 50 条
  • [21] Synthesis of Silver Nanoparticles Using Hesperidin and Its Characterization
    Stephen, Anish
    Seethalakshmi, S.
    INDIAN JOURNAL OF PHARMACOLOGY, 2013, 45 : S76 - S76
  • [22] Synthesis, characterization and antimicrobial investigation of some moxifloxacin metal complexes
    Sadeek, Sadeek A.
    El-Shwiniy, Walaa H.
    El-Attar, Mohamed S.
    SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY, 2011, 84 (01) : 99 - 110
  • [23] Synthesis, characterization and biological studies of a sterically hindered symmetrical nitrogen donor ligand and its metal complexes
    Shiju, C.
    Arish, D.
    Bhuvanesh, N.
    Kumaresan, S.
    POLYHEDRON, 2021, 205 (205)
  • [24] Synthesis, characterization, and biological evaluation of a β-amino carbonyl and its metal complexes using guanine hydrochloride catalyst
    Panwar, Mohit
    Thakuri, Shweta Chand
    Juyal, Vijay Kumar
    Kasana, Virendra
    Nand, Viveka
    JOURNAL OF CHEMICAL SCIENCES, 2025, 137 (02)
  • [25] SYNTHESIS, CHARACTERIZATION AND BIOLOGICAL STUDIES OF QUINAZOLINE BASED HETEROCYCLIC SCHIFF BASE AND ITS TRANSITION METAL COMPLEXES
    Ramu, B.
    Malleswarareddy, P.
    Babu, K. Sudhakar
    HETEROCYCLIC LETTERS, 2021, 11 (04): : 657 - 666
  • [26] Synthesis, characterization and biological applications of curcumin-lysine based schiff base and its metal complexes
    Joice, M. Vimala
    Metilda, P.
    JOURNAL OF COORDINATION CHEMISTRY, 2021, 74 (14) : 2395 - 2406
  • [27] New homoleptic imine derivative of lawsone and its metal complexes: Preparation, characterization, in vitro and in silico biological investigation
    Sheela, Selvaraj Freeda Selva
    Kumar, Karuppiah Arunsunai
    Raman, Natarajan
    APPLIED ORGANOMETALLIC CHEMISTRY, 2024, 38 (02)
  • [28] SYNTHESIS, CHARACTERIZATION AND BIOLOGICAL ACTIVITY OF SOME TARTARATES AND TRANSITION METAL COMPLEXES
    Pawar, S. S.
    Patil, C. S.
    Tadke, V. B.
    Vhankate, S. M.
    Dhanmane, S. A.
    Pathade, G. R.
    Pawar, R. P.
    INTERNATIONAL JOURNAL OF PHARMACEUTICAL SCIENCES AND RESEARCH, 2014, 5 (04): : 1557 - 1565
  • [29] Synthesis, characterization, electrical and biological studies on some bivalent metal complexes
    A. D. Bansod
    R. G. Mahale
    A. S. Aswar
    Russian Journal of Inorganic Chemistry, 2007, 52 : 879 - 883
  • [30] Metal(II) Complexes of the Fluoroquinolone Fleroxacin: Synthesis, Characterization and Biological Profile
    Kostelidou, Alexandra
    Perdih, Franc
    Kljun, Jakob
    Dimou, Foteini
    Kalogiannis, Stavros
    Turel, Iztok
    Psomas, George
    PHARMACEUTICS, 2022, 14 (05)