Association between dietary inflammatory index and chronic kidney disease in middle-aged and elderly populations

被引:2
作者
Guo, Meiqian [1 ,2 ,3 ,4 ]
Lei, Yi [1 ,2 ,3 ,4 ]
Liu, Xueqing [1 ,2 ,3 ,4 ]
Li, Xiang [1 ,2 ,3 ,4 ]
Xu, Yong [1 ,2 ,3 ,4 ]
Zheng, Donghui [1 ,2 ,3 ,4 ]
机构
[1] Xuzhou Med Univ, Affiliated Huaian Hosp, Dept Nephrol, Huaian, Peoples R China
[2] Huaian Second Peoples Hosp, Huaian, Peoples R China
[3] Xuzhou Med Univ, Key Lab Chron Kidney Dis, Huaian, Peoples R China
[4] Xuzhou Med Univ, Affiliated Huaian Hosp, Huaian Key Lab Chron Kidney Dis, Huaian, Peoples R China
来源
FRONTIERS IN NUTRITION | 2024年 / 11卷
基金
中国国家自然科学基金;
关键词
dietary inflammatory index; NHANES; population aging; estimated glomerular filtration rate; albuminuria; chronic kidney disease;
D O I
10.3389/fnut.2024.1335074
中图分类号
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号
100403 ;
摘要
Background A link between food-induced inflammation and common chronic diseases has been identified in studies. However, there was uncertainty about the influence of dietary inflammatory potential on the risk of chronic kidney disease (CKD) among middle-aged and older groups. Our research aimed to examine the connection between dietary inflammatory index (DII) to CKD in people aged 40 years and older. Methods This study comprised ten cycles of the National Health and Nutrition Examination Survey (NHANES) from 1999 to 2018. Linear associations of DII with CKD, low-eGFR, and albuminuria were examined using multiple logistic regression, whereas non-linear associations were assessed by smoothed curve fitting. Besides, we conducted subgroup analyses and interaction tests. Results Of the 23,175 middle-aged and older individuals, a total of 5,847 suffered from CKD, making up 25.23% of all participants. After adjustment for all covariates, we found that increased DII scores were positive with an increased hazard of CKD (OR = 1.08, 95% CI: 1.05, 1.10, p < 0.0001), and the same was shown between DII and low-eGFR (OR = 1.16, 95% CI: 1.13, 1.19, p < 0.0001). After further converting DII into categorical variables, the above relationship still existed. These relations were consistent in different ages, genders, BMI, whether smoking, whether suffering from hypertension, and whether suffering from diabetes, with no significant stratification differences (all P for interaction >0.05). Surprisingly, we did not find a statistically significant correlation of DII to albuminuria after complete adjustment for covariates (OR = 1.02, 95% CI: 1.00, 1.05, p = 0.0742). Even when DII was considered as a categorical variable, this relation was still not statistically significant. Furthermore, we found an association in the shape of a U between DII and low-eGFR in the fully adjusted model, with a turning point at a DII of 1.6. Conclusion Our findings indicated that middle-aged and older persons with greater levels of DII had a significantly higher risk of CKD.
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页数:11
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