COVID-19 infection among patients with cancer in Australia from 2020 to 2022: a national multicentre cohort study

被引：4

作者：

Hall, Victoria G. ^{[1
,2
]}

Sim, Beatrice Z. ^{[1
,2
]}

Lim, Chhay ^{[2
]}

Hocking, Christopher ^{[4
]}

Teo, Teddy ^{[5
]}

Runnegar, Naomi ^{[6
]}

Boan, Peter ^{[7
]}

Heath, Christopher H. ^{[7
,8
]}

Rainey, Natalie ^{[9
]}

Lyle, Megan ^{[9
]}

Steer, Christopher ^{[10
]}

Liu, Eunice ^{[11
]}

Doig, Cassandra ^{[11
]}

Drummond, Kate ^{[12
]}

Charles, Patrick G. P. ^{[12
]}

See, Katharine ^{[13
]}

Lim, Lyn-Li ^{[14
]}

Shum, Omar ^{[15
]}

Bak, Narin ^{[16
]}

Mclachlan, Sue-Anne ^{[17
,18
]}

Singh, Kasha P. ^{[19
]}

Laundy, Nicholas ^{[2
]}

Gallagher, Jenny ^{[2
]}

Stewart, Marcelle ^{[2
]}

Saunders, Natalie R. ^{[2
]}

Klimevski, Emily ^{[2
]}

Demajo, Jessica ^{[2
]}

Reynolds, Gemma ^{[1
,2
]}

Thursky, Karin A. ^{[1
,2
]}

Worth, Leon J. ^{[1
,2
]}

Spelman, Timothy ^{[20
,21
]}

Yong, Michelle K. ^{[1
,2
,3
]}

Slavin, Monica A. ^{[1
,2
,3
]}

Teh, Benjamin W. ^{[1
,2
]}

机构：

[1] Univ Melbourne, Sir Peter MacCallum Dept Oncol, Parkville, Vic, Australia

[2] Peter MacCallum Canc Ctr, Dept Infect Dis, Melbourne, Australia

[3] Royal Melbourne Hosp, Dept Infect Dis, Parkville, Vic, Australia

[4] Lyell McEwin Hosp, Dept Oncol, Adelaide, SA, Australia

[5] Lyell McEwin Hosp, Dept Infect Dis, Adelaide, SA, Australia

[6] Princess Alexandra Hosp, Dept Infect Dis, Brisbane, Qld, Australia

[7] Fiona Stanley Hosp, Dept Infect Dis, Murdoch, WA, Australia

[8] Royal Perth Hosp, PathWest Lab Med, Dept Microbiol, Perth, WA, Australia

[9] Cairns Hosp, Dept Canc Serv, Cairns, Qld, Australia

[10] Albury Wodonga Reg Canc Ctr, Border Med Oncol, Albury, NSW, Australia

[11] Royal North Shore Hosp, Dept Infect Dis, Sydney, NSW, Australia

[12] Austin Hlth, Dept Infect Dis, Heidelberg, Vic, Australia

[13] Northern Hosp, Dept Resp, Epping, Vic, Australia

[14] Monash Univ, Eastern Hlth Clin Sch, Box Hill, Vic, Australia

[15] Wollongong Hosp, Dept Infect Dis, Wollongong, NSW, Australia

[16] Royal Adelaide Hosp, Dept Infect Dis, Adelaide, SA, Australia

[17] St Vincents Hosp, Dept Oncol, Fitzroy, Vic, Australia

[18] Univ Melbourne, Dept Med, Parkville, Vic, Australia

[19] Peninsula Hlth, Dept Infect Dis, Frankston, Vic, Australia

[20] Peter MacCallum Canc Ctr, Dept Biostat & Epidemiol, Melbourne, Vic, Australia

[21] Burnet Inst, Ctr Populat Hlth, Melbourne, Vic, Australia

来源：

LANCET REGIONAL HEALTH-WESTERN PACIFIC | 2023年 / 38卷

关键词：

COVID-19; Severity; Vaccination; Treatment; SEVERITY;

D O I：

10.1016/j.lanwpc.2023.100824

中图分类号：

R19 [保健组织与事业（卫生事业管理）];

学科分类号：

摘要：

Background The global COVID-19 pandemic disproportionately affected certain populations and its management differed between countries. This national study describes characteristics and outcomes of COVID-19 in patients with cancer in Australia.Methods We performed a multicentre cohort study of patients with cancer and COVID-19 from March 2020 to April 2022. Data were analysed to determine varying characteristics between cancer types and changes in outcomes over time. Multivariable analysis was performed to determine risk factors associated with oxygen requirement.Findings 620 patients with cancer from 15 hospitals had confirmed COVID-19. There were 314/620 (50.6%) male patients, median age 63.5 years (IQR 50-72) and majority had solid organ tumours (392/620, 63.2%). The rate of COVID-19 vaccination (>= 1 dose) was 73.4% (455/620). Time from symptom onset to diagnosis was median 1 day (IQR 0-3), patients with haematological malignancy had a longer duration of test positivity. Over the study period, there was a significant decline in COVID-19 severity. Risk factors associated with oxygen requirement included male sex (OR 2.34, 95% CI 1.30-4.20, p = 0.004), age (OR 1.03, 95% CI 1.01-1.06, p = 0.005); not receiving early outpatient therapy (OR 2.78, 95% CI 1.41-5.50, p = 0.003). Diagnosis during the omicron wave was associated with lower odds of oxygen requirement (OR 0.24, 95% CI 0.13-0.43, p < 0.0001).Interpretation Outcomes from COVID-19 in patients with cancer in Australia over the pandemic have improved, potentially related to changing viral strain and outpatient therapies.Copyright (c) 2023 The Author(s). Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

引用

页数：11

共 30 条

[1] Nirmatrelvir Use and Severe Covid-19 Outcomes during the Omicron Surge [J].

Arbel, Ronen ;

Sagy, Yael Wolff ;

Hoshen, Moshe ;

Battat, Erez ;

Lavie, Gil ;

Sergienko, Ruslan ;

Friger, Michael ;

Waxman, Jacob G. ;

Dagan, Noa ;

Balicer, Ran ;

Ben-Shlomo, Yatir ;

Peretz, Alon ;

Yaron, Shlomit ;

Serby, Danielle ;

Hammerman, Ariel ;

Netzer, Doron .

NEW ENGLAND JOURNAL OF MEDICINE, 2022, 387 (09) :790-798

[2] Key lessons from the COVID-19 public health response in Australia [J].

Basseal, J. M. ;

Bennett, C. M. ;

Collignon, P. ;

Currie, B. J. ;

Durrheim, D. N. ;

Leask, J. ;

McBryde, E. S. ;

McIntyre, P. ;

Russell, F. M. ;

Smith, D. W. ;

Sorrell, T. C. ;

Marais, B. J. .

LANCET REGIONAL HEALTH-WESTERN PACIFIC, 2023, 30

[3] Molnupiravir for Oral Treatment of Covid-19 in Nonhospitalized Patients [J].

Bernal, A. Jayk ;

da Silva, M. M. Gomes ;

Musungaie, D. B. ;

Kovalchuk, E. ;

Gonzalez, A. ;

Delos Reyes, V ;

Martin-Quiros, A. ;

Caraco, Y. ;

Williams-Diaz, A. ;

Brown, M. L. ;

Du, J. ;

Pedley, A. ;

Assaid, C. ;

Strizki, J. ;

Grobler, J. A. ;

Shamsuddin, H. H. ;

Tipping, R. ;

Wan, H. ;

Paschke, A. ;

Butterton, J. R. ;

Johnson, M. G. ;

De Anda, C. .

NEW ENGLAND JOURNAL OF MEDICINE, 2022, 386 (06) :509-520

[4] Key findings from the UKCCMP cohort of 877 patients with haematological malignancy and COVID-19: disease control as an important factor relative to recent chemotherapy or anti-CD20 therapy [J].

Booth, Stephen ;

Curley, Helen M. ;

Varnai, Csilla ;

Arnold, Roland ;

Lee, Lennard Y. W. ;

Campton, Naomi A. ;

Cook, Gordon ;

Purshouse, Karin ;

Aries, James ;

Innes, Andrew ;

Cook, Lucy B. ;

Tomkins, Oliver ;

Oram, Helen S. ;

Tilby, Michael ;

Kulasekararaj, Austin ;

Wrench, David ;

Dolly, Saoirse ;

Newsom-Davies, Tom ;

Pettengell, Ruth ;

Gault, Abigail ;

Moody, Sam ;

Mittal, Sajjan ;

Altohami, Mohammed ;

Tillet, Tania ;

Illingworth, Jack ;

Mukherjee, Leena ;

Apperly, Jane ;

Ashcroft, John ;

Rabin, Neil ;

Carmichael, Jonathan ;

Cazier, Jean-Baptiste ;

Kerr, Rachel ;

Middleton, Gary ;

Collins, Graham P. ;

Palles, Claire .

BRITISH JOURNAL OF HAEMATOLOGY, 2022, 196 (04) :892-901

[5]

Communicable Disease Genomics Network, 2022, Variants of concern

[6]

Communicable Disease Network Australia, 2022, CDNA national guidelines for public health units

[7]

Department of Health and Aged Care, 2023, Vaccination numbers and statistics

[8]

Department of Health and Aged Care, 2022, Coronavirus (COVID-19) case numbers and statistics

[9] Immune responses following third COVID-19 vaccination are reduced in patients with hematological compared to patients with solid cancer [J].

Fendler, Annika ;

Shepherd, Scott T. C. ;

Au, Lewis ;

Wilkinson, Katalin A. ;

Wu, Mary ;

Schmitt, Andreas M. ;

Tippu, Zayd ;

Farag, Sheima ;

Rogiers, Aljosja ;

Harvey, Ruth ;

Carlyle, Eleanor ;

Edmonds, Kim ;

Del Rosario, Lyra ;

Lingard, Karla ;

Mangwende, Mary ;

Holt, Lucy ;

Ahmod, Hamid ;

Korteweg, Justine ;

Foley, Tara ;

Barber, Taja ;

Emslie-Henry, Andrea ;

Caulfield-Lynch, Niamh ;

Byrne, Fiona ;

Shum, Benjamin ;

Gerard, Camille L. ;

Deng, Daqi ;

Kjaer, Svend ;

Song, Ok-Ryul ;

Queval, Christophe ;

Kavanagh, Caitlin ;

Wall, Emma C. ;

Carr, Edward J. ;

Namjou, Sina ;

Caidan, Simon ;

Gavrielides, Mike ;

MacRae, James I. ;

Kelly, Gavin ;

Peat, Kema ;

Kelly, Denise ;

Murra, Aida ;

Kelly, Kayleigh ;

O'Flaherty, Molly ;

Shea, Robyn L. ;

Gardner, Gail ;

Murray, Darren ;

Yousaf, Nadia ;

Jhanji, Shaman ;

Van As, Nicholas ;

Young, Kate ;

Furness, Andrew J. S. .

CANCER CELL, 2022, 40 (02) :114-116

[10] Early Remdesivir to Prevent Progression to Severe Covid-19 in Outpatients [J].

Gottlieb, R. L. ;

Vaca, C. E. ;

Paredes, R. ;

Mera, J. ;

Webb, B. J. ;

Perez, G. ;

Oguchi, G. ;

Ryan, P. ;

Nielsen, B. U. ;

Brown, M. ;

Hidalgo, A. ;

Sachdeva, Y. ;

Mittal, S. ;

Osiyemi, O. ;

Skarbinski, J. ;

Juneja, K. ;

Hyland, R. H. ;

Osinusi, A. ;

Chen, S. ;

Camus, G. ;

Abdelghany, M. ;

Davies, S. ;

Behenna-Renton, N. ;

Duff, F. ;

Marty, F. M. ;

Katz, M. J. ;

Ginde, A. A. ;

Brown, S. M. ;

Schiffer, J. T. ;

Hill, J. A. .

NEW ENGLAND JOURNAL OF MEDICINE, 2022, 386 (04) :305-315

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