Efferocytosis: An accomplice of cancer immune escape

被引：10
作者：
Qiu, Hui [1 ,2 ]
Shao, Zhiying [1 ]
Wen, Xin [1 ,2 ]
Liu, Zhengyang [2 ]
Chen, Ziqin [2 ]
Qu, Debao [1 ,2 ]
Ding, Xin [1 ,2 ,3 ]
Zhang, Longzhen [1 ,2 ,3 ]
机构：
[1] Xuzhou Med Univ, Canc Inst, Xuzhou, Jiangsu, Peoples R China
[2] Xuzhou Med Univ, Dept Radiat Oncol, Affiliated Hosp, Xuzhou, Jiangsu, Peoples R China
[3] Xuzhou Med Univ, Dept Radiat Oncol, Affiliated Hosp, 9 Kunpeng North Rd, Xuzhou 221000, Jiangsu, Peoples R China
来源：
BIOMEDICINE & PHARMACOTHERAPY | 2023年 / 167卷
基金：
中国国家自然科学基金;
关键词：
Efferocytosis; Apoptotic cell; Cancer immune escape; Treatment resistance; Immune checkpoint inhibitor; TUMOR-ASSOCIATED MACROPHAGES; RECEPTOR TYROSINE KINASE; FATTY-ACID OXIDATION; APOPTOTIC CELLS; MEMBRANE PHOSPHATIDYLSERINE; DENDRITIC CELLS; BREAST-CANCER; DNA-DAMAGE; ME SIGNAL; CLEARANCE;
D O I：
10.1016/j.biopha.2023.115540
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
The clearance of apoptotic cells by efferocytes such as macrophages and dendritic cells is termed as "efferocytosis", it plays critical roles in maintaining tissue homeostasis in multicellular organisms. Currently, available studies indicate that efferocytosis-related molecules and pathways are tightly associated with cancer development, metastasis and treatment resistance, efferocytosis also induces an immunosuppressive tumor microenvironment and assists cancer cells escape from immune surveillance. In this study, we reviewed the underlying mechanisms of efferocytosis in mediating the occurrence of cancer immune escape, and then emphatically summarized the strategies of using efferocytosis as therapeutic target to enhance the anti-tumor efficacies of immune checkpoint inhibitors, hoping to provide powerful evidences for more effective therapeutic regimens of malignant tumors.
引用
收藏
页数：9
相关论文
共 137 条
  • [1] Apoptotic Cells Promote Their Own Clearance and Immune Tolerance through Activation of the Nuclear Receptor LXR
    A-Gonzalez, Noelia
    Bensinger, Steven J.
    Hong, Cynthia
    Beceiro, Susana
    Bradley, Michelle N.
    Zelcer, Noam
    Deniz, Jose
    Ramirez, Cristina
    Diaz, Mercedes
    Gallardo, German
    Ruiz de Galarreta, Carlos
    Salazar, Jon
    Lopez, Felix
    Edwards, Peter
    Parks, John
    Andujar, Miguel
    Tontonoz, Peter
    Castrillo, Antonio
    [J]. IMMUNITY, 2009, 31 (02) : 245 - 258
  • [2] Cabozantinib in combination with atezolizumab in patients with metastatic castration-resistant prostate cancer: results from an expansion cohort of a multicentre, open-label, phase 1b trial (COSMIC-021)
    Agarwal, Neeraj
    McGregor, Bradley
    Maughan, Benjamin L.
    Dorff, Tanya B.
    Kelly, William
    Fang, Bruno
    McKay, Rana R.
    Singh, Parminder
    Pagliaro, Lance
    Dreicer, Robert
    Srinivas, Sandy
    Loriot, Yohann
    Vaishampayan, Ulka
    Goel, Sanjay
    Curran, Dominic
    Panneerselvam, Ashok
    Schwickart, Martin
    Choueiri, Toni K.
    Pal, Sumanta
    [J]. LANCET ONCOLOGY, 2022, 23 (07) : 899 - 909
  • [3] The clearance of dead cells by efferocytosis
    Boada-Romero, Emilio
    Martinez, Jennifer
    Heckmann, Bradlee L.
    Green, Douglas R.
    [J]. NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2020, 21 (07) : 398 - 414
  • [4] Inhibition of eosinophil migration by lactoferrin
    Bournazou, Irini
    Mackenzie, Karen J.
    Duffin, Rodger
    Rossi, Adriano G.
    Gregory, Christopher D.
    [J]. IMMUNOLOGY AND CELL BIOLOGY, 2010, 88 (02) : 220 - 223
  • [5] Apoptotic human cells inhibit migration of granulocytes via release of lactoferrin
    Bournazou, Irini
    Pound, John D.
    Duffin, Rodger
    Bournazos, Stylianos
    Melville, Lynsey A.
    Brown, Simon B.
    Rossi, Adriano G.
    Gregory, Christopher D.
    [J]. JOURNAL OF CLINICAL INVESTIGATION, 2009, 119 (01) : 20 - 32
  • [6] AXL Is a Logical Molecular Target in Head and Neck Squamous Cell Carcinoma
    Brand, Toni M.
    Iida, Mari
    Stein, Andrew P.
    Corrigan, Kelsey L.
    Braverman, Cara M.
    Coan, John P.
    Pearson, Hannah E.
    Bahrar, Harsh
    Fowler, Tyler L.
    Bednarz, Bryan P.
    Saha, Sandeep
    Yang, David
    Gill, Parkash S.
    Lingen, Mark W.
    Saloura, Vassiliki
    Villaflor, Victoria M.
    Salgia, Ravi
    Kimple, Randall J.
    Wheeler, Deric L.
    [J]. CLINICAL CANCER RESEARCH, 2015, 21 (11) : 2601 - 2612
  • [7] AXL Mediates Resistance to Cetuximab Therapy
    Brand, Toni M.
    Iida, Mari
    Stein, Andrew P.
    Corrigan, Kelsey L.
    Braverman, Cara M.
    Luthar, Neha
    Toulany, Mahmoud
    Gill, Parkash S.
    Salgia, Ravi
    Kimple, Randall J.
    Wheeler, Deric L.
    [J]. CANCER RESEARCH, 2014, 74 (18) : 5152 - 5164
  • [8] Apoptosis disables CD31-mediated cell detachment from phagocytes promoting binding and engulfment
    Brown, S
    Heinisch, I
    Ross, E
    Shaw, K
    Buckley, CD
    Savill, J
    [J]. NATURE, 2002, 418 (6894) : 200 - 203
  • [9] Unconventional Rac-GEF activity is mediated through the Dock180-ELMO complex
    Brugnera, E
    Haney, L
    Grimsley, C
    Lu, MJ
    Walk, SF
    Tosello-Trampont, AC
    Macara, IG
    Madhani, H
    Fink, GR
    Ravichandran, KS
    [J]. NATURE CELL BIOLOGY, 2002, 4 (08) : 574 - 582
  • [10] The expression and significance of efferocytosis and immune checkpoint related molecules in pancancer samples and the correlation of their expression with anticancer drug sensitivity
    Cheng, Lin
    Weng, Bangbi
    Jia, Changsheng
    Zhang, Lin
    Hu, Bin
    Deng, Li
    Mou, Nan
    Sun, Fengjun
    Hu, Jing
    [J]. FRONTIERS IN PHARMACOLOGY, 2022, 13
12345678910