Optical Biosensor Based on Surface Plasmon Resonance Nanostructure for the Detection of Mycobacterium Tuberculosis Bacteria with Ultra-High Efficiency and Detection Accuracy

Mycobacterium tuberculosis bacteria is an illness that affects many people worldwide. Early diagnosis is crucial for patient care and can lower the death rate. As a result, sensitive and rapid detection of mycobacterium tuberculosis bacteria in the blood is crucial. In this paper, a novel surface plasmon resonance (SPRE) sensor consisting of a coupling prism, silver (Ag), barium titanate (BaTiO3) and graphene (Gr) layers is presented. The transfer matrix (TM) technique is used for the analysis of the SPRE structure. The Ag and BaTiO3 thicknesses and the number of Gr sheets are optimized to get the highest sensitivity of the proposed SPRE biosensor. The full width at half maximum (FWHM), detection accuracy (DA) and figure of merit (FOM) are investigated. The best performance has been obtained with 65 nm (Ag), and 9 nm (BaTiO3). The number of Gr layers is investigated and optimized to two layers. The highest sensitivity of 300 deg./RIU has been obtained for the proposed SPRE biosensor when the optimized thicknesses are employed. Compared with existing SPRE biosensors in the literature, the proposed sensor exhibits greater sensitivity. The excellent performance makes this SPRE-based sensor promising to be used in numerous biosensing applications.