Correlation between T-lymphocyte CD4+ and Total Lymphocyte Count (TLC), hemoglobin, Neutrophil to Lymphocyte Ratio (NLR) and T-lymphocyte CD4+/CD8+ ratioin HIV patients at Prof. Dr. I.G.N.G Ngoerah Hospital, Denpasar, Bali, Indonesia

Background: Human Immunodeficiency Virus (HIV) is an RNA virus from the Retroviridae family, Lentiviri subfamily, which attacks the immune system, especially T lymphocytes, namely Cluster of Differentiation 4+ (CD4+) cells. Human Immunodeficiency Virus destroys T lymphocyte CD4+ cells, decreasing immunity against opportunistic infections. For monitoring of HIV, an examination of T lymphocyte CD4+ cells and complete blood counts were conducted. Methods: A cross-sectional quantitative analytic study was conducted from October 2021 to January 2022 at Prof. Dr. IGNG Ngoerah Hospital. Measurements were made on the total number of lymphocytes, hemoglobin levels, neutrophil-tolymphocyte ratio (NLR), CD4+ levels and CD4+/CD8+ ratios. We analyze normality data using Kolmogorov-Smirnov and correlation using Pearson and Spearman tests. The p-value < 0.05 was considered significant. Results: 56 patients met the inclusion and exclusion criteria, with 46 males (82.1%) and 10 females (17.9%). Mean age 38.98 & PLUSMN;11.58 years, mean total lymphocyte 0.64 x 103 & mu;L, median T lymphocyte CD4+ 133.50 sel/mm3, mean hemoglobin 10.11 & PLUSMN;1.49 g/dL, median NLR 6.51, median CD4+/CD8+ ratio 0.06. The hemoglobin variable was normally distributed, while the other variables were abnormal. The Pearson Correlation test showed a significant relationship between T lymphocytes CD4+ and hemoglobin with r=0.329 (p=0.013). Spearman's Correlation test showed a significant relationship between T lymphocytes CD4+ and NLR, total lymphocytes, CD4+/CD8+ ratio with r-0.334 (p=0.012), r=0.777 (p=0.000), r=0.729 (p=0.000) respectively. Conclusion: There is a strong and significant correlation between the level of T lymphocytes CD4+ and total lymphocyte count and the ratio of CD4+/CD8+, a weak and significant correlation between the level of T lymphocytes CD4+ with hemoglobin and NLR in HIV patients at Prof. Dr. IGNG Ngoerah Hospital.