Asymmetric total synthesis of (+)-propolisbenzofuran B

被引：1

作者：

Sen, Biswajit ^{[1
,2
]}

Bera, Mainak ^{[1
]}

Singh, Maya Shankar ^{[2
]}

Hajra, Saumen ^{[1
]}

机构：

[1] Ctr Biomed Res SGPGIMS Campus, Raebareli Rd, Lucknow 226014, UP, India

[2] Banaras Hindu Univ, Inst Sci, Dept Chem, Varanasi 221005, UP, India

来源：

CHEMICAL COMMUNICATIONS | 2023年 / 59卷 / 53期

关键词：

BIOLOGICAL-PROPERTIES; PROPOLIS; BENZOFURANS; CLEAVAGE; ANTIBACTERIAL; ACETYLATION; DERIVATIVES; OXIDATION; PHENOLS; FACILE;

D O I：

10.1039/d3cc02054a

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The first asymmetric total synthesis of (+)-propolisbenzofuran B is accomplished in 11 steps with an overall yield of 11.9%. The key steps are tandem deacetylative Sonogashira coupling-annulation reaction to synthesize the 2-substituted benzofuran core, stereoselective syn-aldol reaction and Friedel-Crafts cyclization to install the desired stereocenters & third-ring, and Stille coupling for C-acetylation.

引用

页码：8254 / 8257

页数：4

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