Small molecule ectonucleotide pyrophosphatase/phosphodiesterase 1 inhibitors in cancer immunotherapy for harnessing innate immunity

被引：5
|
作者：
Choi, Junwon [1 ]
机构：
[1] Ajou Univ, Dept Mol Sci & Technol, Suwon, Gyeonggi, South Korea
来源：
BULLETIN OF THE KOREAN CHEMICAL SOCIETY | 2023年 / 44卷 / 02期
基金：
新加坡国家研究基金会;
关键词：
cancer immunotherapy; cGAMP; ENPP1; inhibitor; innate immunity; STING; CYCLIC GMP-AMP; NUCLEOTIDE PYROPHOSPHATASE; EXTRACELLULAR CGAMP; POTENT INHIBITORS; BYSTANDER CELLS; HUMAN NPP1; DERIVATIVES; HYDROLYSIS; 2ND-MESSENGER; ENPP1;
D O I：
10.1002/bkcs.12646
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Ectonucleotide pyrophosphatase/phosphodiesterase 1 (ENPP1) was recently identified as a major hydrolase of an endogenous stimulator of interferon genes (STING) agonist, 2 ',3 '-cyclic guanosine monophosphate-adenosine monophosphate (cGAMP). ENPP1 is a promising therapeutic target in cancer immunotherapy, in which the inhibition of ENPP1 enhances anticancer immunity via STING-mediated innate immune activation. This review highlights the role of ENPP1 in innate immunity and the recent discovery of small molecule ENPP1 inhibitors as immunomodulators in cancer immunotherapy.
引用
收藏
页码：88 / 99
页数：12
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