Association of the matrix metalloproteinases (MMPs) family gene polymorphisms and the risk of coronavirus disease 2019 (COVID-19); implications of contribution for development of neurological symptoms in the COVID-19 patients

被引：8

作者：

Ramezani, Samaneh ^{[1
]}

Ezzatifar, Fatemeh ^{[2
,3
]}

Hojjatipour, Tahereh ^{[4
]}

Hemmatzadeh, Maryam ^{[5
]}

Shabgah, Arezoo Gowhari ^{[6
]}

Navashenaq, Jamshid Gholizadeh ^{[7
]}

Aslani, Saeed ^{[8
]}

Shomali, Navid ^{[5
]}

Arabi, Mohsen ^{[9
]}

Babaie, Farhad ^{[10
]}

Jadidi-Niaragh, Farhad ^{[11
,12
]}

Hosseinzadeh, Ramin ^{[8
]}

Feizisani, Fahimeh ^{[13
]}

Khodayar, Sara ^{[14
]}

Safari, Roghaiyeh ^{[15
,16
,17
,18
]}

Mohammadi, Hamed ^{[14
,19
]}

机构：

[1] Mashhad Univ Med Sci, Immunol Res Ctr, Med Sch, Inflammat & Inflammatory Dis Div, Mashhad, Razavi Khorasan, Iran

[2] Mazandaran Univ Med Sci, Fac Med, Mol & Cell Biol Res Ctr, Sari, Iran

[3] Mazandaran Univ Med Sci, Student Res Comm, Sari, Iran

[4] Univ Tehran Med Sci, Students Res Ctr, Sch Allied Med, Dept Hematol & Blood Transfus, Tehran, Iran

[5] Tabriz Univ Med Sci, Student Res Comm, Tabriz, Iran

[6] Bam Univ Med Sci, Sch Med, Bam, Iran

[7] Bam Univ Med Sci, Noncommunicable Dis Res Ctr, Bam, Iran

[8] Univ Tehran Med Sci, Sch Med, Dept Immunol, Tehran, Iran

[9] Alborz Univ Med Sci, Sch Med, Dept Physiol Pharmacol & Med Phys, Karaj, Iran

[10] Urmia Univ Med Sci, Cellular & Mol Res Ctr, Orumiyeh, Iran

[11] Tabriz Univ Med Sci, Immunol Res Ctr, Tabriz, Iran

[12] Tabriz Univ Med Sci, Fac Med, Dept Immunol, Tabriz, Iran

[13] Sarab Fac Med Sci, Student Res Comm, Sarab, Iran

[14] Alborz Univ Med Sci, Noncommunicable Dis Res Ctr, Karaj, Iran

[15] Mol & Cellular Epigenet GIGA, Sart Tilman Par Liege, Belgium

[16] Univ Liege, GemblouxAgro Bio Tech, Mol & Cellular Biol TERRA, Sart Tilman Par Liege, Belgium

[17] Univ Liege, Gembloux, Belgium

[18] Univ Liege, Mol & Cellular Biol TERRA, Gembloux Agro Bio Tech, Gembloux, Belgium

[19] Alborz Univ Med Sci, Sch Med, Dept Immunol, Karaj, Iran

来源：

MOLECULAR BIOLOGY REPORTS | 2023年 / 50卷 / 01期

关键词：

Coronavirus disease 2019; Central nervous system; Matrix metalloproteinases; Genetic polymorphism; Neurological symptoms; GELATINASE-B; EXPRESSION; ACE2;

D O I：

10.1007/s11033-022-07907-y

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Background Seemingly, the Matrix metalloproteinases (MMPs) play a role in the etiopathogenesis of coronavirus disease 2019 (COVID-19). Here in this study, we determined the association of MMP9 rs3918242, MMP3 rs3025058, and MMP2 rs243865 polymorphisms with the risk of COVID-19, especially in those with neurological syndrome (NS). Methods We enrolled 500 patients with COVID-19 and 500 healthy individuals. To genotype the target SNPs, the Real-time allelic discrimination technique was used. To determine serum levels of MMPs, Enzyme-linked immunosorbent assay (ELISA) was exerted. Results The MMP9 gene rs3918242 and MMP3 gene rs3025058 SNP were significantly associated with increased COVID-19 risk and susceptibility to COVID-19 with NS. The serum level of MMP-9 and MMP-3 was significantly higher in COVID-19 cases compared with the healthy controls. Serum MMP-9 and MMP-3 levels were also higher in COVID-19 subjects with NS in comparison to the healthy controls. The polymorphisms in MMP genes were not associated with serum level of MMPs. Conclusion MMP9 and MMP3 gene polymorphisms increases the susceptibility to COVID-19 as well as COVID-19 with neurologic syndrome, but they probably have no role in the regulation of serum MMP-9 and MMP-3 levels.

引用

页码：173 / 183

页数：11

共 37 条

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