Dinuclear Zinc Catalyzed [3+2] Annulation of Benzylideneindolinones Access to CF3-Containing 2,3-Pyrrolidinyl Dispirooxindoles

被引：5

作者：

Zhai, Ying-Hui ^{[1
,2
]}

Guo, Ya-Jun ^{[1
,2
]}

Du, Si-Si ^{[1
,2
]}

Wang, Min-Can ^{[1
,2
]}

Jia, Shi-Kun ^{[1
,2
]}

Hua, Yuan-Zhao ^{[1
,2
]}

机构：

[1] Zhengzhou Univ, Coll Chem, 100 Sci Rd, Zhengzhou 450000, Henan, Peoples R China

[2] Zhengzhou Univ, Inst Green Catalysis, 100 Sci Rd, Zhengzhou 450000, Henan, Peoples R China

来源：

ADVANCED SYNTHESIS & CATALYSIS | 2023年 / 365卷 / 18期

关键词：

dinuclear zinc catalyst; 2,3-pyrrolidinyl dispirooxindoles; benzylideneindolinone; ENANTIOSELECTIVE SYNTHESIS; ASYMMETRIC-SYNTHESIS; AZOMETHINE YLIDES; CYCLOADDITION; CONSTRUCTION; FLUORINE;

D O I：

10.1002/adsc.202300705

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

This report has realized the catalytic asymmetric [3+2] annulation of benzylideneindolinones with CF3-containing isatin-derived azomethine ylides for the first time, in which the organocatalysis has failed. In the presence of dinuclear zinc catalysts, a series of functionalized 2,3-pyrrolidinyl dispirooxindoles have been synthesized in good yields with excellent stereoselectivity under mild reaction conditions. This protocol can be run on a gram scale and a possible catalytic mechanism is proposed.

引用

页码：3088 / 3093

页数：6

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