The prognostic role of single cell invasion and nuclear diameter in early oral tongue squamous cell carcinoma

被引：2

作者：

Almangush, Alhadi ^{[1
,2
,3
,4
]}

Hagstrom, Jaana ^{[1
,5
,6
]}

Haglund, Caj ^{[5
,7
,8
]}

Kowalski, Luiz Paulo ^{[9
]}

Coletta, Ricardo D. ^{[10
,11
]}

Makitie, Antti A. ^{[3
,8
,12
,13
,14
]}

Salo, Tuula ^{[1
,15
]}

Leivo, Ilmo ^{[16
]}

机构：

[1] Univ Helsinki, Dept Pathol, HaartmaninkatuPOB 21, FI-00014 Helsinki, Finland

[2] Univ Turku, Inst Biomed, Pathol, Turku, Finland

[3] Univ Helsinki, Fac Med, Res Program Syst Oncol, Helsinki, Finland

[4] Misurata Univ, Fac Dent, Misurata, Libya

[5] Univ Helsinki, Res Programs Unit, Translat Canc Med, POB 63, Helsinki 00014, Finland

[6] Univ Turku, Inst Dent, Turku, Finland

[7] Univ Helsinki, Dept Surg, Helsinki, Finland

[8] Helsinki Univ Hosp, POB 263, FI-00029 Helsinki, Finland

[9] Univ Sao Paulo, Dept Head & Neck Surg & Otorhinolaryngol, Dept Head & Neck Surg, AC Camargo Canc Ctr,Med Sch, BR-05402000 Sao Paulo, SP, Brazil

[10] Univ Estadual Campinas, Sch Dent, Dept Oral Diag, BR-13414018 Piracicaba, SP, Brazil

[11] Univ Estadual Campinas, Sch Dent, Grad Program Oral Biol, BR-13414018 Piracicaba, SP, Brazil

[12] Univ Helsinki, Dept Otorhinolaryngol Head & Neck Surg, POB 263, FI-00029 Helsinki, Finland

[13] Karolinska Univ Hosp, Karolinska Inst, Dept Clin Sci Intervent & Technol, Stockholm, Sweden

[14] Karolinska Univ Hosp, Stockholm, Sweden

[15] Univ Helsinki, Dept Oral & Maxillofacial Dis, Helsinki, Finland

[16] Univ Turku, Turku Univ Cent Hosp, Inst Biomed, Pathol, Turku 20520, Finland

来源：

BMC CANCER | 2024年 / 24卷 / 01期

关键词：

Oral tongue cancer; Single cell invasion; Large nuclei; Early stage; Survival; HISTOPATHOLOGIC PARAMETERS; CANCER; RISK; EXPRESSION; MORPHOLOGY; SURVIVAL; SIZE;

D O I：

10.1186/s12885-024-11954-y

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

BackgroundThe clinical significance of single cell invasion and large nuclear diameter is not well documented in early-stage oral tongue squamous cell carcinoma (OTSCC).MethodsWe used hematoxylin and eosin-stained sections to evaluate the presence of single cell invasion and large nuclei in a multicenter cohort of 311 cases treated for early-stage OTSCC.ResultsSingle cell invasion was associated in multivariable analysis with poor disease-specific survival (DSS) with a hazard ratio (HR) of 2.089 (95% CI 1.224-3.566, P = 0.007), as well as with disease-free survival (DFS) with a HR of 1.666 (95% CI 1.080-2.571, P = 0.021). Furthermore, large nuclei were associated with worse DSS (HR 2.070, 95% CI 1.216-3.523, P = 0.007) and with DFS in multivariable analysis (HR 1.645, 95% CI 1.067-2.538, P = 0.024).ConclusionSingle cell invasion and large nuclei can be utilized for classifying early OTSCC into risk groups.

引用

页数：8

共 32 条

[31] Significance of depth of invasion determined by MRI in cT1N0 tongue squamous cell carcinoma
Xu, Chunmiao
Yuan, Junhui
Kang, Liuqing
Zhang, Xiaoxian
Wang, Lifeng
Chen, Xuejun
Yao, Qi
Li, Hailiang
[J]. SCIENTIFIC REPORTS, 2020, 10 (01)
[32] DNA ploidy, nuclear size, proliferation index and DNA-hypomethylation in ovarian cancer
Zeimet, Alain G.
Fiegl, Heidi
Goebel, Georg
Kopp, Francis
Allasia, Claude
Reimer, Daniel
Steppan, Ilona
Mueller-Holzner, Elisabeth
Ehrlich, Melanie
Marth, Christian
[J]. GYNECOLOGIC ONCOLOGY, 2011, 121 (01) : 24 - 31

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