The prognostic role of single cell invasion and nuclear diameter in early oral tongue squamous cell carcinoma

被引：2
作者：
Almangush, Alhadi [1 ,2 ,3 ,4 ]
Hagstrom, Jaana [1 ,5 ,6 ]
Haglund, Caj [5 ,7 ,8 ]
Kowalski, Luiz Paulo [9 ]
Coletta, Ricardo D. [10 ,11 ]
Makitie, Antti A. [3 ,8 ,12 ,13 ,14 ]
Salo, Tuula [1 ,15 ]
Leivo, Ilmo [16 ]
机构：
[1] Univ Helsinki, Dept Pathol, HaartmaninkatuPOB 21, FI-00014 Helsinki, Finland
[2] Univ Turku, Inst Biomed, Pathol, Turku, Finland
[3] Univ Helsinki, Fac Med, Res Program Syst Oncol, Helsinki, Finland
[4] Misurata Univ, Fac Dent, Misurata, Libya
[5] Univ Helsinki, Res Programs Unit, Translat Canc Med, POB 63, Helsinki 00014, Finland
[6] Univ Turku, Inst Dent, Turku, Finland
[7] Univ Helsinki, Dept Surg, Helsinki, Finland
[8] Helsinki Univ Hosp, POB 263, FI-00029 Helsinki, Finland
[9] Univ Sao Paulo, Dept Head & Neck Surg & Otorhinolaryngol, Dept Head & Neck Surg, AC Camargo Canc Ctr,Med Sch, BR-05402000 Sao Paulo, SP, Brazil
[10] Univ Estadual Campinas, Sch Dent, Dept Oral Diag, BR-13414018 Piracicaba, SP, Brazil
[11] Univ Estadual Campinas, Sch Dent, Grad Program Oral Biol, BR-13414018 Piracicaba, SP, Brazil
[12] Univ Helsinki, Dept Otorhinolaryngol Head & Neck Surg, POB 263, FI-00029 Helsinki, Finland
[13] Karolinska Univ Hosp, Karolinska Inst, Dept Clin Sci Intervent & Technol, Stockholm, Sweden
[14] Karolinska Univ Hosp, Stockholm, Sweden
[15] Univ Helsinki, Dept Oral & Maxillofacial Dis, Helsinki, Finland
[16] Univ Turku, Turku Univ Cent Hosp, Inst Biomed, Pathol, Turku 20520, Finland
来源：
BMC CANCER | 2024年 / 24卷 / 01期
关键词：
Oral tongue cancer; Single cell invasion; Large nuclei; Early stage; Survival; HISTOPATHOLOGIC PARAMETERS; CANCER; RISK; EXPRESSION; MORPHOLOGY; SURVIVAL; SIZE;
D O I：
10.1186/s12885-024-11954-y
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
BackgroundThe clinical significance of single cell invasion and large nuclear diameter is not well documented in early-stage oral tongue squamous cell carcinoma (OTSCC).MethodsWe used hematoxylin and eosin-stained sections to evaluate the presence of single cell invasion and large nuclei in a multicenter cohort of 311 cases treated for early-stage OTSCC.ResultsSingle cell invasion was associated in multivariable analysis with poor disease-specific survival (DSS) with a hazard ratio (HR) of 2.089 (95% CI 1.224-3.566, P = 0.007), as well as with disease-free survival (DFS) with a HR of 1.666 (95% CI 1.080-2.571, P = 0.021). Furthermore, large nuclei were associated with worse DSS (HR 2.070, 95% CI 1.216-3.523, P = 0.007) and with DFS in multivariable analysis (HR 1.645, 95% CI 1.067-2.538, P = 0.024).ConclusionSingle cell invasion and large nuclei can be utilized for classifying early OTSCC into risk groups.
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页数：8
相关论文
共 32 条
  • [1] For early-stage oral tongue cancer, depth of invasion and worst pattern of invasion are the strongest pathological predictors for locoregional recurrence and mortality
    Almangush, Alhadi
    Bello, Ibrahim O.
    Coletta, Ricardo D.
    Makitie, Antti A.
    Makinen, Laura K.
    Kauppila, Joonas H.
    Pukkila, Matti
    Hagstrom, Jaana
    Laranne, Jussi
    Soini, Ylermi
    Kosma, Veli-Matti
    Koivunen, Petri
    Kelner, Natalie
    Kowalski, Luiz Paulo
    Grenman, Reidar
    Leivo, Ilmo
    Laara, Esa
    Salo, Tuula
    [J]. VIRCHOWS ARCHIV, 2015, 467 (01) : 39 - 46
  • [2] Development of a New Outcome Prediction Model in Early-stage Squamous Cell Carcinoma of the Oral Cavity Based on Histopathologic Parameters With Multivariate Analysis: The Aditi-Nuzhat Lymph-node Prediction Score (ANLPS) System
    Arora, Aditi
    Husain, Nuzhat
    Bansal, Ankur
    Neyaz, Azfar
    Jaiswal, Ritika
    Jain, Kavitha
    Chaturvedi, Arun
    Anand, Nidhi
    Malhotra, Kiranpreet
    Shukla, Saumya
    [J]. AMERICAN JOURNAL OF SURGICAL PATHOLOGY, 2017, 41 (07) : 950 - 960
  • [3] Immunohistochemical expression of CD44 in oral squamous cell carcinoma in relation to histomorphological parameters and clinicopathological factors
    Boxberg, Melanie
    Goetz, Carolin
    Haidari, Selgai
    Dorfner, Christiane
    Jesinghaus, Moritz
    Drecoll, Enken
    Boskov, Marko
    Wolff, Klaus D.
    Weichert, Wilko
    Haller, Bernhard
    Kolk, Andreas
    [J]. HISTOPATHOLOGY, 2018, 73 (04) : 559 - 572
  • [4] Cancer cell invasion and EMT marker expression: a three-dimensional study of the human cancer-host interface
    Bronsert, P.
    Enderle-Ammour, K.
    Bader, M.
    Timme, S.
    Kuehs, M.
    Csanadi, A.
    Kayser, G.
    Kohler, I.
    Bausch, D.
    Hoeppner, J.
    Hopt, U. T.
    Keck, T.
    Stickeler, E.
    Passlick, B.
    Schilling, O.
    Reiss, C. P.
    Vashist, Y.
    Brabletz, T.
    Berger, J.
    Lotz, J.
    Olesch, J.
    Werner, M.
    Wellner, U. F.
    [J]. JOURNAL OF PATHOLOGY, 2014, 234 (03) : 410 - 422
  • [5] Buhmeida A, 2006, ANTICANCER RES, V26, P455
  • [6] Prognostic significance of tumor budding and single cell invasion in gastric adenocarcinoma
    Che, Keying
    Zhao, Yang
    Qu, Xiao
    Pang, Zhaofei
    Ni, Yang
    Zhang, Tiehong
    Du, Jiajun
    Shen, Hongchang
    [J]. ONCOTARGETS AND THERAPY, 2017, 10 : 1039 - 1047
  • [7] Diverging incidence trends of oral tongue cancer compared to other head and neck cancers in young adults in France
    Deneuve, Sophie
    Perol, Olivia
    Dantony, Emmanuelle
    Guizard, Anne-Valerie
    Bossard, Nadine
    Virard, Francois
    Fervers, Beatrice
    [J]. INTERNATIONAL JOURNAL OF CANCER, 2022, 150 (08) : 1301 - 1309
  • [8] El-Naggar AK, 2017, WHO CLASSIFICATION H
  • [9] Oral tongue carcinoma among young patients: An analysis of risk factors and survival
    Farquhar, Douglas R.
    Tanner, April M.
    Masood, Maheer M.
    Patel, Sagar R.
    Hackman, Trevor G.
    Olshan, Andrew F.
    Mazul, Angela L.
    Zevallos, Jose P.
    [J]. ORAL ONCOLOGY, 2018, 84 : 7 - 11
  • [10] Plasticity of cell migration: a multiscale tuning model
    Friedl, Peter
    Wolf, Katarina
    [J]. JOURNAL OF CELL BIOLOGY, 2010, 188 (01) : 11 - 19
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