An Overview of the Structure-Activity Relationship in Novel Antimicrobial Thiazoles Clubbed with Various Heterocycles (2017-2023)

被引：8
|
作者：
Ungureanu, Daniel [1 ,2 ]
Tiperciuc, Brindusa [1 ]
Nastasa, Cristina [1 ]
Ionut, Ioana [1 ]
Marc, Gabriel [1 ]
Oniga, Ilioara [3 ]
Oniga, Ovidiu [1 ]
机构：
[1] Iuliu Hatieganu Univ Med & Pharm, Fac Pharm, Dept Pharmaceut Chem, 41 Victor Babes St, Cluj Napoca 400012, Romania
[2] Prof Dr Ion Chiricuta Oncol Inst, 34-36 Republicii St, Cluj Napoca 400015, Romania
[3] Iuliu Hatieganu Univ Med & Pharm, Fac Pharm, Dept Pharmacognosy, 12 Ion Creanga St, Cluj Napoca 400010, Romania
来源：
PHARMACEUTICS | 2024年 / 16卷 / 01期
关键词：
thiazole; structure-activity relationship; antimicrobial; heterocycles; hybrid compounds; ANTIBACTERIAL ACTIVITY; BIOLOGICAL EVALUATION; MOLECULAR DOCKING; DERIVATIVES; ANTIOXIDANT; ANTIFUNGAL; INHIBITION; DESIGN;
D O I：
10.3390/pharmaceutics16010089
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Antimicrobial resistance is an increasing problem for global public health. One of the strategies to combat this issue is the synthesis of novel antimicrobials through rational drug design based on extensive structure-activity relationship studies. The thiazole nucleus is a prominent feature in the structure of many authorized antimicrobials, being clubbed with different heterocycles. The purpose of this review is to study the structure-activity relationship in antimicrobial thiazoles clubbed with various heterocycles, as reported in the literature between 2017 and 2023, in order to offer an overview of the last years in terms of antimicrobial research and provide a helpful instrument for future research in the field.
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页数：54
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