Therapeutic developments in pancreatic cancer

被引：188

作者：

Hu, Z. Ian ^{[1
]}

O'Reilly, Eileen M. ^{[2
,3
]}

机构：

[1] Univ Texas MD Anderson Canc Ctr, Dept Gastrointestinal Med Oncol, Houston, TX USA

[2] Mem Sloan Kettering Canc Ctr, Dept Med, Gastrointestinal Oncol Serv, New York, NY 10021 USA

[3] Weill Cornell Med Coll, New York, NY 10075 USA

来源：

NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY | 2024年 / 21卷 / 01期

关键词：

GROWTH-FACTOR RECEPTOR; PHASE-II TRIAL; TUMOR-INFILTRATING MACROPHAGES; T-CELL IMMUNITY; OPEN-LABEL; DUCTAL ADENOCARCINOMA; ADJUVANT GEMCITABINE; TERM SURVIVORS; NAB-PACLITAXEL; PATIENTS PTS;

D O I：

10.1038/s41575-023-00840-w

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Pancreatic ductal adenocarcinoma (PDAC) has a rising incidence and is one of the most lethal human malignancies. Much is known regarding the biology and pathophysiology of PDAC, but translating this knowledge to the clinic to improve patient outcomes has been challenging. In this Review, we discuss advances and practice-changing trials for PDAC. We briefly review therapeutic failures as well as ongoing research to refine the standard of care, including novel biomarkers and clinical trial designs. In addition, we highlight contemporary areas of research, including poly(ADP-ribose) polymerase inhibitors, KRAS-targeted therapies and immunotherapies. Finally, we discuss the future of pancreatic cancer research and areas for improvement in the next decade. The incidence of pancreatic ductal adenocarcinoma (PDAC) is rising. In this Review, Hu and O'Reilly summarize the latest advances and clinical trials for the treatment of PDAC, including biomarkers, targeted therapies and immunotherapy as well as novel clinical trial designs. They also discuss emerging therapeutic options for this disease.

引用

页码：7 / 24

页数：18

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