Synthesis of tris(indolyl)methanes by using dimethyl carbonate as a single carbon source via C-H functionalization approach

被引：2

作者：

Nath, Priyanka ^{[1
]}

Deb, Mohit L. ^{[2
,3
]}

Baruah, Pranjal K. ^{[1
]}

机构：

[1] Gauhati Univ, Dept Appl Sci, GUIST, Gauhati 781014, Assam, India

[2] Univ Sci & Technol Meghalaya, Adv Res Ctr, Baridua 793101, Meghalaya, India

[3] Univ Sci & Technol Meghalaya, Dept Chem, Baridua 793101, Meghalaya, India

来源：

CHEMICAL PAPERS | 2024年 / 78卷 / 02期

关键词：

Tris(indolyl)methanes; Indoles; Dimethyl carbonate; Copper catalyst; Carbon source; INDOLES; EFFICIENT; BONDS; BIS; ENAMINES; IODINE;

D O I：

10.1007/s11696-023-03150-2

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Here, we report a copper acetate/tert-butyl hydroperoxide-mediated reaction of N-substituted indoles with dimethyl carbonate under heating to give tris(indolyl)methanes via alpha-C-H functionalization of the methoxy group of dimethyl carbonate. The central methine carbon in the product comes from the dimethyl carbonate molecule, which is used as a substrate as well as a reaction medium. The reaction uses a cheap and environmentally benign copper metal catalyst which makes the process useful. This is the first report of tris(indolyl)methane synthesis using dimethyl carbonate as a single carbon source.

引用

页码：1117 / 1124

页数：8

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