Liquid-liquid phase separation regulates alpha-synuclein aggregate and mitophagy in Parkinson's disease

被引：4
|
作者：
Hou, Kaiying [1 ]
Liu, Tingting [1 ]
Li, Jingwen [1 ]
Xian, Meiyan [1 ]
Sun, Lin [2 ]
Wei, Jianshe [1 ]
机构：
[1] Henan Univ, Sch Life Sci, Kaifeng, Peoples R China
[2] Henan Univ, Coll Chem & Mol Sci, Kaifeng 475004, Peoples R China
来源：
FRONTIERS IN NEUROSCIENCE | 2023年 / 17卷
基金：
中国国家自然科学基金;
关键词：
liquid-liquid phase separation; Parkinson's disease; mitophagy; alpha-synuclein; PINK1-Parkin; QUALITY-CONTROL; BETA-SYNUCLEIN; AUTOPHAGY; PINK1; UBIQUITIN; MITOCHONDRIA; P62/SQSTM1; DRIVES; DYSFUNCTION; ACTIVATION;
D O I：
10.3389/fnins.2023.1250532
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Parkinson's disease (PD) is the second most common neurodegenerative disease in the world, and alpha-synuclein (& alpha;-syn) abnormal aggregate and mitochondrial dysfunction play a crucial role in its pathological development. Recent studies have revealed that proteins can form condensates through liquid-liquid phase separation (LLPS), and LLPS has been found to be widely present in & alpha;-syn aberrant aggregate and mitophagy-related protein physiological processes. This review summarizes the occurrence of & alpha;-syn LLPS and its influencing factors, introduces the production and transformation of the related protein LLPS during PINK1-Parkin-mediated mitophagy, hoping to provide new ideas and methods for the study of PD pathology.
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页数：11
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