Liquid-liquid phase separation regulates alpha-synuclein aggregate and mitophagy in Parkinson's disease

被引：4
|
作者：
Hou, Kaiying [1 ]
Liu, Tingting [1 ]
Li, Jingwen [1 ]
Xian, Meiyan [1 ]
Sun, Lin [2 ]
Wei, Jianshe [1 ]
机构：
[1] Henan Univ, Sch Life Sci, Kaifeng, Peoples R China
[2] Henan Univ, Coll Chem & Mol Sci, Kaifeng 475004, Peoples R China
来源：
FRONTIERS IN NEUROSCIENCE | 2023年 / 17卷
基金：
中国国家自然科学基金;
关键词：
liquid-liquid phase separation; Parkinson's disease; mitophagy; alpha-synuclein; PINK1-Parkin; QUALITY-CONTROL; BETA-SYNUCLEIN; AUTOPHAGY; PINK1; UBIQUITIN; MITOCHONDRIA; P62/SQSTM1; DRIVES; DYSFUNCTION; ACTIVATION;
D O I：
10.3389/fnins.2023.1250532
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Parkinson's disease (PD) is the second most common neurodegenerative disease in the world, and alpha-synuclein (& alpha;-syn) abnormal aggregate and mitochondrial dysfunction play a crucial role in its pathological development. Recent studies have revealed that proteins can form condensates through liquid-liquid phase separation (LLPS), and LLPS has been found to be widely present in & alpha;-syn aberrant aggregate and mitophagy-related protein physiological processes. This review summarizes the occurrence of & alpha;-syn LLPS and its influencing factors, introduces the production and transformation of the related protein LLPS during PINK1-Parkin-mediated mitophagy, hoping to provide new ideas and methods for the study of PD pathology.
引用
收藏
页数：11
相关论文
共 50 条
  • [31] Autoantibodies to alpha-synuclein in inherited Parkinson's disease
    Papachroni, Katerina K.
    Ninkina, Natalia
    Papapanagiotou, Angeliki
    Hadjigeorgiou, Georgios M.
    Xiromerisiou, Georgia
    Papadimitriou, Alexandros
    Kalofoutis, Anastasios
    Buchman, Vladimir L.
    JOURNAL OF NEUROCHEMISTRY, 2007, 101 (03) : 749 - 756
  • [32] Liquid-liquid phase separation of α-synuclein is highly sensitive to sequence complexity
    Mahapatra, Anindita
    Newberry, Robert W.
    PROTEIN SCIENCE, 2024, 33 (04)
  • [33] A Characterization of Misfolded Alpha-Synuclein in Parkinson's Disease
    Shannon, Daniel
    Bugada, John-Paul
    Collins, Ethan
    Fischer, Ellie
    Hellard, Delaney
    Hoffman, Trevor
    Kellogg, Nick
    Peters, Kyle
    Poetker, Garret
    Young, Logan
    Diao, JiaJie
    FASEB JOURNAL, 2020, 34
  • [34] Alpha-Synuclein and Mitochondrial Dysfunction in Parkinson’s Disease
    Dolgacheva L.P.
    Fedotova E.I.
    Abramov A.Y.
    Berezhnov A.V.
    Biochemistry (Moscow), Supplement Series A: Membrane and Cell Biology, 2018, 12 (1) : 10 - 19
  • [35] Alpha-synuclein and presynaptic functionImplications for Parkinson’s disease
    Simon Lykkebo
    Poul Henning Jensen
    NeuroMolecular Medicine, 2002, 2 : 115 - 129
  • [36] Role of alpha-synuclein and tau in Parkinson's disease
    Trojanowski, JQ
    MOVEMENT DISORDERS, 2004, 19 : S2 - S2
  • [37] Targeting Alpha-Synuclein for the Treatment of Parkinson's Disease
    Rohn, Troy T.
    CNS & NEUROLOGICAL DISORDERS-DRUG TARGETS, 2012, 11 (02) : 174 - 179
  • [38] The central role of alpha-synuclein in Parkinson's disease
    Halliday, G.
    JOURNAL OF NEUROCHEMISTRY, 2015, 134 : 54 - 54
  • [39] Methylation Regulates Alpha-Synuclein Expression and Is Decreased in Parkinson's Disease Patients' Brains
    Jowaed, Ahmad
    Schmitt, Ina
    Kaut, Oliver
    Wuellner, Ullrich
    JOURNAL OF NEUROSCIENCE, 2010, 30 (18): : 6355 - 6359
  • [40] Alpha-synuclein and the Parkinson's disease drug pipeline
    Espay, Alberto J.
    McFarthing, Kevin
    PARKINSONISM & RELATED DISORDERS, 2023, 111
12345