Liquid-liquid phase separation regulates alpha-synuclein aggregate and mitophagy in Parkinson's disease

被引：4
|
作者：
Hou, Kaiying [1 ]
Liu, Tingting [1 ]
Li, Jingwen [1 ]
Xian, Meiyan [1 ]
Sun, Lin [2 ]
Wei, Jianshe [1 ]
机构：
[1] Henan Univ, Sch Life Sci, Kaifeng, Peoples R China
[2] Henan Univ, Coll Chem & Mol Sci, Kaifeng 475004, Peoples R China
来源：
FRONTIERS IN NEUROSCIENCE | 2023年 / 17卷
基金：
中国国家自然科学基金;
关键词：
liquid-liquid phase separation; Parkinson's disease; mitophagy; alpha-synuclein; PINK1-Parkin; QUALITY-CONTROL; BETA-SYNUCLEIN; AUTOPHAGY; PINK1; UBIQUITIN; MITOCHONDRIA; P62/SQSTM1; DRIVES; DYSFUNCTION; ACTIVATION;
D O I：
10.3389/fnins.2023.1250532
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Parkinson's disease (PD) is the second most common neurodegenerative disease in the world, and alpha-synuclein (& alpha;-syn) abnormal aggregate and mitochondrial dysfunction play a crucial role in its pathological development. Recent studies have revealed that proteins can form condensates through liquid-liquid phase separation (LLPS), and LLPS has been found to be widely present in & alpha;-syn aberrant aggregate and mitophagy-related protein physiological processes. This review summarizes the occurrence of & alpha;-syn LLPS and its influencing factors, introduces the production and transformation of the related protein LLPS during PINK1-Parkin-mediated mitophagy, hoping to provide new ideas and methods for the study of PD pathology.
引用
收藏
页数：11
相关论文
共 50 条
  • [21] Interplay between tau and α-synuclein liquid-liquid phase separation
    Siegert, Anna
    Rankovic, Marija
    Favretto, Filippo
    Ukmar-Godec, Tina
    Strohaeker, Timo
    Becker, Stefan
    Zweckstetter, Markus
    PROTEIN SCIENCE, 2021, 30 (07) : 1326 - 1336
  • [22] Alpha-synuclein and Parkinson disease
    Hui Liu1
    Neural Regeneration Research, 2007, (04) : 239 - 243
  • [23] A novel, label-free liquid crystal biosensor for Parkinson's disease related alpha-synuclein
    Yang, Xiuxiu
    Li, Haiyu
    Zhao, Xiaofang
    Liao, Wei
    Zhang, Claire Xi
    Yang, Zhongqiang
    CHEMICAL COMMUNICATIONS, 2020, 56 (40) : 5441 - 5444
  • [24] Parkinson's Disease, Cortical Dysfunction, and Alpha-Synuclein
    Caviness, John N.
    Lue, Lih-Fen
    Beach, Thomas G.
    Hentz, Joseph G.
    Adler, Charles H.
    Sue, Lucia
    Sadeghi, Ramin
    Driver-Dunckley, Erika
    Evidente, Virgilio G.
    Sabbagh, Marwan N.
    Shill, Holly A.
    Walker, Douglas G.
    MOVEMENT DISORDERS, 2011, 26 (08) : 1436 - 1442
  • [25] Targeting Alpha-Synuclein as a Therapy for Parkinson's Disease
    Fields, Carroll Rutherford
    Bengoa-Vergniory, Nora
    Wade-Martins, Richard
    FRONTIERS IN MOLECULAR NEUROSCIENCE, 2019, 12
  • [26] Modeling Parkinson's Disease With the Alpha-Synuclein Protein
    Gomez-Benito, Monica
    Granado, Noelia
    Garcia-Sanz, Patricia
    Michel, Anne
    Dumoulin, Mireille
    Moratalla, Rosario
    FRONTIERS IN PHARMACOLOGY, 2020, 11
  • [27] Alpha-synuclein and the prion hypothesis in Parkinson's disease
    Melki, R.
    REVUE NEUROLOGIQUE, 2018, 174 (09) : 644 - 652
  • [28] Lipids and alpha-synuclein aggregation in Parkinson's disease
    Broersen, K.
    Davletov, B.
    MOVEMENT DISORDERS, 2007, 22 (12) : VI - VI
  • [29] Familial Parkinson's disease - The awakening of alpha-synuclein
    Goedert, M
    NATURE, 1997, 388 (6639) : 232 - 233
  • [30] Sumoylation of alpha-synuclein in the pathogenesis of parkinson's disease
    Engelender, S.
    JOURNAL OF NEUROCHEMISTRY, 2019, 150 : 48 - 48
12345