Chemical Synthesis of Peptides and Proteins Bearing Base-Labile Post-Translational Modifications: Evolution of the Methods in Four Decades

被引：6

作者：

Ma, Wenjie ^{[1
]}

Liu, Han ^{[1
]}

Li, Xuechen ^{[1
]}

机构：

[1] Univ Hong Kong, Dept Chem, State Key Lab Synthet Chem, Pokfulam Rd, Hong Kong, Peoples R China

来源：

CHEMBIOCHEM | 2023年 / 24卷 / 20期

关键词：

base-labile posttranslation modification; chemical protein synthesis; chemical ligation; S-palmitoylation; O-acetylation; SOLID-PHASE SYNTHESIS; MYELIN PROTEOLIPID PROTEIN; LIPID-MODIFIED PROTEINS; SAFETY-CATCH LINKER; N-RAS PROTEIN; CHEMOENZYMATIC SYNTHESIS; CHARACTERISTIC LIPOPEPTIDES; TERMINAL LIPOHEXAPEPTIDE; EFFICIENT SYNTHESIS; ENZYMATIC-SYNTHESIS;

D O I：

10.1002/cbic.202300348

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The S-palmitoylation on Cys residue and O-acetylation on Ser/Thr residues are two types of base-labile post-translational modifications (PTMs) in cells. The lability of these PTMs to bases and nucleophiles makes the peptides/proteins bearing S-palmitoyl or O-acetyl groups challenging synthetic targets, which cannot be prepared via the standard Fmoc-SPPS and native chemical ligation. In this review, we summarized the efforts towards their preparation in the past 40 years, with the focus on the evolution of synthetic methods.

引用

页数：12

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