Lymphatic Filariasis Elimination Status: Wuchereria bancrofti Infections in Human Populations after Five Effective Rounds of Mass Drug Administration in Zambia

被引:3
作者
Matapo, Belem Blamwell [1 ,2 ]
Mpabalwani, Evans Mwila [3 ]
Kaonga, Patrick [1 ]
Simuunza, Martin Chitolongo [4 ]
Bakyaita, Nathan [2 ]
Masaninga, Freddie [2 ]
Siyumbwa, Namasiku [5 ]
Siziya, Seter [6 ]
Shamilimo, Frank [5 ]
Muzongwe, Chilweza [5 ]
Mwase, Enala T. T. [4 ]
Sikasunge, Chummy Sikalizyo [4 ]
机构
[1] Univ Zambia, Sch Publ Hlth, Ridgeway Campus,POB 50516, Lusaka, Zambia
[2] WHO, Corner Andrew Mwenya Beit Rd,POB 32346, Lusaka, Zambia
[3] Univ Zambia, Sch Med, Ridgeway Campus,POB 50516, Lusaka, Zambia
[4] Univ Zambia, Sch Vet Med, Great East Rd Campus,POB 32379, Lusaka, Zambia
[5] Minist Hlth Headquarters Ndeke House, POB 30205, Lusaka, Zambia
[6] Copperbelt Univ, Michael Chilufya Sata Sch Med, POB 71191, Ndola, Zambia
关键词
lymphatic filariasis; pre-TAS; prevalence; antigenaemia; microfilariae; Zambia; AMICROFILARAEMIC INDIVIDUALS; DIETHYLCARBAMAZINE;
D O I
10.3390/tropicalmed8070333
中图分类号
R51 [传染病];
学科分类号
100401 ;
摘要
Lymphatic filariasis (LF), also commonly known as elephantiasis, is a neglected tropical disease (NTD) caused by filarial parasites. The disease is transmitted via a bite from infected mosquitoes. The bites of these infected mosquitoes deposit filarial parasites, Wuchereria or Brugia, whose predilection site is the lymphatic system. The damage to the lymph system causes swelling in the legs, arms, and genitalia. A mapping survey conducted between 2003 and 2011 determined LF as being endemic in Zambia in 96 out of 116 districts. Elimination of LF is known to be possible by stopping the spread of the infection through large-scale preventive chemotherapy. Therefore, mass drug administration (MDA) with diethylcarbamazine citrate (DEC) (6 mg/kg) and Albendazole (400 mg) for Zambia has been conducted and implemented in all endemic districts with five effective rounds. In order to determine whether LF prevalence has been sufficiently reduced to levels less than 2% antigenemia and less than 1% microfilaremia, a pre-transmission assessment survey (pre-TAS) was conducted. Therefore, post-MDA pre-TAS was conducted between 2021 and 2022 in 80 districts to determine the LF prevalence. We conducted a cross-sectional seroprevalence study involving 600 participants in each evaluation unit (EU) or each district. The study sites (sentinel and spot-check sites) were from districts that were the implementation units (IUs) of the LF MDA. These included 80 districts from the 9 provinces. A total of 47,235 people from sentinel and spot-check locations were tested. Of these, valid tests were 47,052, of which 27,762 (59%) were females and 19,290 (41%) were males. The survey revealed in the 79/80 endemic districts a prevalence of Wb antigens of 0.14% and 0.0% prevalence of microfilariae. All the surveyed districts had an optimum prevalence of less than 2% for antigenaemia, except for Chibombo district. The majority of participants that tested positive for Wuchereria bancrofti (Wb) Antigens (Ag) were those that had 2, 3, and 4 rounds of MDA. Surprisingly, individuals that had 1 round of MDA were not found to have circulating antigens of Wb. The study showed that all the surveyed districts, except for Chibombo, passed pre-TAS. This further implies that there is a need to conduct transmission assessment surveys (TASs) in these districts.
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页数:9
相关论文
共 32 条
[1]  
[Anonymous], About Us
[2]   DIETHYLCARBAMAZINE IN THE TREATMENT OF PATIENTS WITH ONCHOCERCIASIS [J].
AWADZI, K ;
GILLES, HM .
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 1992, 34 (04) :281-288
[3]   Age-dependent prevalence of asymptomatic amicrofilaraemic individuals in a Wuchereria bancrofti-endemic region of India [J].
Beuria, MK ;
Bal, MS ;
Mandal, NN ;
Das, MK .
TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE, 2003, 97 (03) :297-298
[4]  
Buckley J. J. C., 1946, JOUR HELMINTHOL, V21, P111, DOI 10.1017/S0022149X00032041
[5]   Risk factors associated with failing pre-transmission assessment surveys (pre-TAS) in lymphatic filariasis elimination programs: Results of a multi-country analysis [J].
Burgert-Brucker, Clara R. ;
Zoerhoff, Kathryn L. ;
Headland, Maureen ;
Shoemaker, Erica A. ;
Stelmach, Rachel ;
Karim, Mohammad Jahirul ;
Batcho, Wilfrid ;
Bougouma, Clarisse ;
Bougma, Roland ;
Didier, Biholong Benjamin ;
Georges, Nko'Ayissi ;
Marfo, Benjamin ;
Lemoine, Jean Frantz ;
Pangaribuan, Helena Ullyartha ;
Wijayanti, Eksi ;
Coulibaly, Yaya Ibrahim ;
Doumbia, Salif Seriba ;
Rimal, Pradip ;
Salissou, Adamou Bacthiri ;
Bah, Yukaba ;
Mwingira, Upendo ;
Nshala, Andreas ;
Muheki, Edridah ;
Shott, Joseph ;
Yevstigneyeva, Violetta ;
Ndayishimye, Egide ;
Baker, Margaret ;
Kraemer, John ;
Brady, Molly .
PLOS NEGLECTED TROPICAL DISEASES, 2020, 14 (06) :1-17
[6]   Transmission Assessment Surveys (TAS) to Define Endpoints for Lymphatic Filariasis Mass Drug Administration: A Multicenter Evaluation [J].
Chu, Brian K. ;
Deming, Michael ;
Biritwum, Nana-Kwadwo ;
Bougma, Windtare R. ;
Dorkenoo, Ameyo M. ;
El-Setouhy, Maged ;
Fischer, Peter U. ;
Gass, Katherine ;
de Pena, Manuel Gonzalez ;
Mercado-Hernandez, Leda ;
Kyelem, Dominique ;
Lammie, Patrick J. ;
Flueckiger, Rebecca M. ;
Mwingira, Upendo J. ;
Noordin, Rahmah ;
Owusu, Irene Offei ;
Ottesen, Eric A. ;
Pavluck, Alexandre ;
Pilotte, Nils ;
Rao, Ramakrishna U. ;
Samarasekera, Dilhani ;
Schmaedick, Mark A. ;
Settinayake, Sunil ;
Simonsen, Paul E. ;
Supali, Taniawati ;
Taleo, Fasihah ;
Torres, Melissa ;
Weil, Gary J. ;
Won, Kimberly Y. .
PLOS NEGLECTED TROPICAL DISEASES, 2013, 7 (12)
[7]   Dynamics of antigenemia and transmission intensity of Wuchereria bancrofti following cessation of mass drug administration in a formerly highly endemic region of Mali [J].
Coulibaly, Yaya I. ;
Coulibaly, Siaka Y. ;
Dolo, Housseini ;
Konate, Siaka ;
Diallo, Abdallah A. ;
Doumbia, Salif S. ;
Soumaoro, Lamine ;
Coulibaly, Michel E. ;
Dicko, Ilo ;
Sangare, Moussa B. ;
Dembele, Benoit ;
Sangare, Modibo ;
Dembele, Massitan ;
Toure, Yeya T. ;
Kelly-Hope, Louise ;
Polman, Katja ;
Kyelem, Dominique ;
Traore, Sekou F. ;
Bockarie, Moses ;
Klion, Amy D. ;
Nutman, Thomas B. .
PARASITES & VECTORS, 2016, 9
[8]   Brugia Rapid™ antibody responses in communities of Indonesia in relation to the results of 'transmission assessment surveys' (TAS) for the lymphatic filariasis elimination program [J].
Dewi, Rita M. ;
Tuti, Sekar ;
Ganefa, Sitti ;
Anwar, Chairiyah ;
Larasati, Ria ;
Ariyanti, Endah ;
Herjati, Herty ;
Brady, Molly .
PARASITES & VECTORS, 2015, 8
[9]   In Wuchereria bancrofti filariasis, asymptomatic microfilaraemia does not progress to amicrofilaraemic lymphatic disease [J].
Dissanayake, S .
INTERNATIONAL JOURNAL OF EPIDEMIOLOGY, 2001, 30 (02) :394-399
[10]   TOLERANCE OF DIETHYLCARBAMAZINE BY MICROFILAREMIC AND AMICROFILARAEMIC INDIVIDUALS IN AN ENDEMIC AREA OF BANCROFTIAN FILARIASIS, RECIFE, BRAZIL [J].
DREYER, G ;
PIRES, ML ;
DEANDRADE, LD ;
LOPES, E ;
MEDEIROS, Z ;
TENORIO, J ;
COUTINHO, A ;
NOROES, J ;
FIGUEREDOSILVA, J .
TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE, 1994, 88 (02) :232-236