Measures of Early-life Behavior and Later Psychopathology in the LifeCycle Project- EU Child Cohort Network: A Cohort Description

被引：12

作者：

Nader, Johanna L. ^{[1
]}

Lopez-Vicente, Monica ^{[2
,3
]}

Julvez, Jordi ^{[2
,4
]}

Guxens, Monica ^{[2
]}

Cadman, Tim ^{[5
]}

Elhakeem, Ahmed ^{[5
]}

Jarvelin, Marjo-Riitta ^{[6
]}

Rautio, Nina ^{[6
]}

Miettunen, Jouko ^{[6
,7
,8
]}

El Marroun, Hanan ^{[3
,9
,10
]}

Melchior, Maria ^{[11
]}

Heude, Barbara ^{[12
]}

Charles, Marie-Aline ^{[12
,13
]}

Yang, Tiffany C. ^{[14
]}

McEachan, Rosemary R. C. ^{[14
]}

Wright, John ^{[14
]}

Polanska, Kinga ^{[15
]}

Carson, Jennie ^{[16
]}

Lin, Ashleigh ^{[16
]}

Rauschert, Sebastian ^{[16
]}

Huang, Rae-Chi ^{[16
]}

Popovic, Maja ^{[17
,18
]}

Richiardi, Lorenzo ^{[17
,18
]}

Corpeleijn, Eva ^{[19
]}

Cardol, Marloes ^{[19
]}

Mikkola, Tuija M. ^{[20
,21
]}

Eriksson, Johan G. ^{[20
,22
,23
,24
,25
,26
]}

Salika, Theodosia ^{[27
]}

Inskip, Hazel ^{[27
,28
]}

Vinther, Johan Lerbech ^{[29
]}

Strandberg-Larsen, Katrine ^{[29
]}

Guerlich, Kathrin ^{[30
]}

Grote, Veit ^{[30
]}

Koletzko, Berthold ^{[30
]}

Vafeiadi, Marina ^{[31
]}

Sunyer, Jordi ^{[2
]}

Jaddoe, Vincent W. V. ^{[9
,10
]}

Harris, Jennifer R. ^{[32
,33
]}

机构：

[1] Norwegian Inst Publ Hlth, Dept Genet & Bioinformat, Div Hlth Data & Digitalisat, Oslo, Norway

[2] Inst Salud Global Barcelona, ISGlobal, Barcelona, Spain

[3] Erasmus MC, Dept Child & Adolescent Psychiat, Rotterdam, Netherlands

[4] Hosp Universitari St Joan de Reus, Inst Invest Sanitaria Pere Virgili, Reus, Spain

[5] Univ Bristol, Bristol Med Sch, Populat Hlth Sci, MRC,Integrat Epidemiol Unit, Bristol, Avon, England

[6] Univ Oulu, Ctr Life Course Hlth Res, Oulu, Finland

[7] Oulu Univ Hosp, Med Res Ctr Oulu, Oulu, Finland

[8] Univ Oulu, Oulu, Finland

[9] Erasmus MC, Dept Pediat, Rotterdam, Netherlands

[10] Erasmus MC, Generat R Study Grp, Rotterdam, Netherlands

[11] Sorbonne Univ, INSERM, Inst Pierre Louis Epidemiol & Sante Publ, Paris, France

[12] Univ Paris, INSERM, Inst Natl Rech Agron, Ctr Res Epidemiol & Stat, Paris, France

[13] Inst Natl Etud Demog, Unite Mixte Inserm Ined EFS Elfe, Paris, France

[14] Bradford Teaching Hosp NHS Fdn Trust, Bradford Inst Hlth Res, Bradford, W Yorkshire, England

[15] Med Univ Lodz, Dept Hyg & Epidemiol, Lodz, Poland

[16] Univ Western Australia, Telethon Kids Inst, Perth, WA, Australia

[17] Univ Turin, Dept Med Sci, Canc Epidemiol Unit, Turin, Italy

[18] CPO Piemonte, Turin, Italy

[19] Univ Med Ctr Groningen, Dept Epidemiol, Groningen, Netherlands

[20] Folkhalsan Res Ctr, Helsinki, Finland

[21] Univ Helsinki, Fac Med, Clinicum, Uusimaa, Finland

[22] Natl Inst Hlth & Welf, Publ Hlth Promot Unit, Helsinki, Finland

[23] Univ Helsinki, Dept Gen Practice & Primary Hlth Care, Helsinki, Finland

[24] Helsinki Univ Hosp, Helsinki, Finland

[25] Agcy Sci Technol & Res, Singapore Inst Clin Sci, Singapore, Singapore

[26] Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Obstet & Gynaecol, Singapore, Singapore

[27] Univ Southampton, Southampton Gen Hosp, Med Res Council, Lifecourse Epidemiol Unit, Southampton, Hants, England

[28] Univ Southampton, Univ Hosp Southampton NHS Fdn Trust, NIHR Southampton Biomed Res Ctr, Southampton, Hants, England

[29] Univ Copenhagen, Dept Publ Hlth, Sect Epidemiol, Copenhagen, Denmark

[30] Ludwig Maximilian Univ Munich, Univ Hosp, Dr von Hauner Childrens Hosp, Dept Pediat,Div Metab & Nutr Med, Munich, Germany

[31] Univ Crete, Fac Med, Dept Social Med, Iraklion, Greece

[32] Norwegian Inst Publ Hlth, Ctr Fertil & Hlth, Div Hlth Data & Digitalizat, Oslo, Norway

[33] Norwegian Inst Publ Hlth, Dept Genet & Bioinformat, Sandakerveien 24 C, N-0473 Oslo, Norway

来源：

JOURNAL OF EPIDEMIOLOGY | 2023年 / 33卷 / 06期

基金：

英国惠康基金; 英国医学研究理事会; 欧盟地平线“2020”;

关键词：

birth and pregnancy cohorts; child behavior and mental health; population epidemiology; child development; DataSHIELD; GENERATION R; BIRTH COHORT; PROFILE; DISEASE; DATASHIELD; PREGNANCY; MORTALITY; UPDATE;

D O I：

10.2188/jea.JE20210241

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

Background: The EU LifeCycle Project was launched in 2017 to combine, harmonize, and analyze data from more than 250,000 participants across Europe and Australia, involving cohorts participating in the EU-funded LifeCycle Project. The purpose of this cohort description is to provide a detailed overview of the major measures within mental health domains that are available in 17 European and Australian cohorts participating in the LifeCycle Project.Methods: Data on cognitive, behavioral, and psychological development has been collected on participants from birth until adulthood through questionnaire and medical data. We developed an inventory of the available data by mapping individual instruments, domain types, and age groups, providing the basis for statistical harmonization across mental health measures.Results: The mental health data in LifeCycle contain longitudinal and cross-sectional data from birth throughout the life course, covering domains across a wide range of behavioral and psychopathology indicators and outcomes, including executive function, depression, ADHD, and cognition. These data span a unique combination of qualitative data collected through behavioral/cognitive/mental health questionnaires and examination, as well as data from biological samples and indices in the form of imaging (MRI, fetal ultrasound) and DNA methylation data. Harmonized variables on a subset of mental health domains have been developed, providing statistical equivalence of measures required for longitudinal meta-analyses across instruments and cohorts.Conclusion: Mental health data harmonized through the LifeCycle project can be used to study life-course trajectories and exposure-outcome models that examine early life risk factors for mental illness and develop predictive markers for later-life disease.

引用

页码：321 / 331

页数：11

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