Assessment of normal pulmonary development using functional magnetic resonance imaging techniques

被引:7
作者
Avena-Zampieri, Carla L. [1 ,2 ]
Hutter, Jana [2 ]
Deprez, Maria [2 ,7 ]
Payette, Kelly [2 ,7 ]
Hall, Megan [1 ,2 ,3 ]
Uus, Alena [2 ,7 ]
Nanda, Surabhi [3 ]
Milan, Anna [4 ]
Seed, Paul T. [1 ]
Rutherford, Mary [2 ]
Greenough, Anne [1 ,5 ,6 ]
Story, Lisa [1 ,2 ,3 ]
机构
[1] Kings Coll London, Dept Women & Childrens Hlth, London, England
[2] Ctr Developing Brain, Sch Biomed Engn & Imaging Sci, Kings Coll London, London, England
[3] Guys & St Thomas NHS Fdn Trust, Fetal Med Unit, London, England
[4] Guys & St Thomas NHS Fdn Trust, Neonatal Unit, London, England
[5] Kings Coll Hosp London, Neonatal Unit, London, England
[6] St Thomas NHS Fdn Trusts, Natl Inst Hlth, Kings Coll London, Care Res Biomed Res Ctr based Guys, London, England
[7] Kings Coll London, Sch Biomed Engineer ing & Imaging Sci, Dept Biomed Engn, London, England
基金
美国国家卫生研究院; 英国工程与自然科学研究理事会; 英国惠康基金;
关键词
fetal magnetic resonance imaging; lung development; pre-natal prediction; T2*; FETAL LUNG-VOLUMES; HYPERTENSION; PREDICTION; PRETERM; BODY; AGE;
D O I
10.1016/j.ajogmf.2023.100935
中图分类号
R71 [妇产科学];
学科分类号
100211 ;
摘要
BACKGROUND: The mainstay of assessment of the fetal lungs in clin-ical practice is via evaluation of pulmonary size, primarily using 2D ultra-sound and more recently with anatomical magnetic resonance imaging. The emergence of advanced magnetic resonance techniques such as T2* relaxometry in combination with the latest motion correction post-processing tools now facilitates assessment of the metabolic activity or perfusion of fetal pulmonary tissue in vivo.OBJECTIVE: This study aimed to characterize normal pulmonary devel-opment using T2* relaxometry, accounting for fetal motion across gestation.METHODS: Datasets from women with uncomplicated pregnancies that delivered at term, were analyzed. All subjects had undergone T2-weighted imaging and T2* relaxometry on a Phillips 3T magnetic resonance imaging system antenatally. T2* relaxometry of the fetal thorax was performed using a gradient echo single-shot echo planar imaging sequence. Following correction for fetal motion using slice-to-volume reconstruction, T2* maps were gener-ated using in-house pipelines. Lungs were manually segmented and mean T2* values calculated for the right and left lungs individually, and for both lungs combined. Lung volumes were generated from the segmented images, and the right and left lungs, as well as both lungs combined were assessed.RESULTS: Eighty-seven datasets were suitable for analysis. The mean gestation at scan was 29.9 +/- 4.3 weeks (range: 20.6-38.3) and mean gestation at delivery was 40 +/- 1.2 weeks (range: 37.1 -42.4). Mean T2* values of the lungs increased over gestation for right and left lungs individually and for both lungs assessed together (P=.003; P=.04; P=.003, respectively). Right, left, and total lung vol-umes were also strongly correlated with increasing gestational age (P<.001 in all cases).CONCLUSION: This large study assessed developing lungs using T2* imaging across a wide gestational age range. Mean T2* values increased with gestational age, which may reflect increasing perfusion and metabolic requirements and alterations in tissue composition as gestation advances. In the future, evaluation of findings in fetuses with conditions known to be associated with pulmonary morbidity may lead to enhanced prognostica-tion antenatally, consequently improving counseling and perinatal care planning.
引用
收藏
页数:9
相关论文
共 50 条
[31]   Techniques and Applications of Dynamic Contrast Enhanced Magnetic Resonance Imaging in Cancer [J].
Barnes, Stephanie L. ;
Whisenant, Jennifer G. ;
Li, Xia ;
Yankeelov, Thomas E. .
2014 36TH ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY (EMBC), 2014, :4264-4267
[32]   Advanced Magnetic Resonance Imaging Techniques in the Preterm Brain: Methods and Applications [J].
Tao, Joshua D. ;
Neil, Jeffrey J. .
CURRENT PEDIATRIC REVIEWS, 2014, 10 (01) :56-64
[33]   Is Common Trunk Anomaly Frequent in Hemifacial Spasm? Comparison with Normal Subjects Using Magnetic Resonance Imaging [J].
Ujihara, Masaki ;
Suzuki, Shun ;
Kobayashi, Masahito ;
Hirata, Sachiko ;
Takabatake, Kazuhiko ;
Hatayama, Toru ;
Fujimaki, Takamitsu .
WORLD NEUROSURGERY, 2024, 188 :e53-e58
[34]   Assessment of Brain Lesions in Type 2 Diabetes Mellitus and Hypertension using Magnetic Resonance Imaging [J].
Alshammari, Qurain Turki ;
Salih, Mohammed ;
Gameraddin, Moawia ;
Abdelmalik, Bushra ;
Alshoabi, Sultan ;
Elnour, Elfadil ;
Yousif, Elgeili .
INTERNATIONAL JOURNAL OF BIOMEDICINE, 2020, 10 (04) :382-386
[35]   Development of fetal cerebral cortex: assessment of the folding conditions with post-mortem Magnetic Resonance Imaging [J].
Zhang, Zhonghe ;
Liu, Shuwei ;
Lin, Xiangtao ;
Sun, Bo ;
Yu, Taifei ;
Geng, Hequn .
INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE, 2010, 28 (06) :537-543
[36]   Magnetic Resonance Imaging in the Prognostic Evaluation of Patients with Pulmonary Arterial Hypertension [J].
Swift, Andrew J. ;
Capener, Dave ;
Johns, Chris ;
Hamilton, Neil ;
Rothman, Alex ;
Elliot, Charlie ;
Condliffe, Robin ;
Charalampopoulos, Athanasios ;
Rajaram, Smitha ;
Lawrie, Allan ;
Campbell, Michael J. ;
Wild, Jim M. ;
Kiely, David G. .
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2017, 196 (02) :228-239
[37]   Prognostic Significance of Cardiac Magnetic Resonance Imaging in Children With Pulmonary Hypertension [J].
Moledina, Shahin ;
Pandya, Bejal ;
Bartsota, Margarita ;
Mortensen, Kristian H. ;
McMillan, Merlin ;
Quyam, Sadia ;
Taylor, Andrew M. ;
Haworth, Sheila G. ;
Schulze-Neick, Ingram ;
Muthurangu, Vivek .
CIRCULATION-CARDIOVASCULAR IMAGING, 2013, 6 (03) :407-414
[38]   Phase-Contrast Magnetic Resonance Quantification of Normal Pulmonary Venous Return [J].
Goo, Hyun Woo ;
Al-Otay, Abdulmajeed ;
Grosse-Wortmann, Lars ;
Wu, Shengping ;
Macgowan, Christopher K. ;
Yoo, Shi-Joon .
JOURNAL OF MAGNETIC RESONANCE IMAGING, 2009, 29 (03) :588-594
[39]   Right ventricular reverse remodeling after pulmonary endarterectomy: magnetic resonance imaging and clinical and right heart catheterization assessment [J].
Berman, Marius ;
Gopalan, Deepa ;
Sharples, Linda ;
Screaton, Nick ;
Maccan, Caroline ;
Sheares, Karen ;
Pepke-Zaba, Joanna ;
Dunning, John ;
Tsui, Steven ;
Jenkins, David P. .
PULMONARY CIRCULATION, 2014, 4 (01) :36-44
[40]   Assessment of Pulmonary Arterial Pressure by Velocity-Encoded Cine Magnetic Resonance Imaging in Children With Congenital Heart Disease [J].
Sugimoto, Masaya ;
Kajino, Hiroki ;
Kajihama, Aya ;
Nakau, Kouichi ;
Murakami, Noboru ;
Azuma, Hiroshi .
CIRCULATION JOURNAL, 2013, 77 (12) :3015-3022